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ReMogliflozin etabonate

Product Name
ReMogliflozin etabonate
CAS No.
442201-24-3
Chemical Name
ReMogliflozin etabonate
Synonyms
EOS-61714;GSK 189075;GSK189075A;GSK-189075A;GSK 189075A;ReMogliflozin etabonate;UAOCLDQAQNNEAX-ABMICEGHSA-N;Remogliflozin etabonate (GSK189075);Remogliflozin etabonate, 10 mM in DMSO;442201-24-3
CBNumber
CB72582855
Molecular Formula
C26H38N2O9
Formula Weight
522.6
MOL File
442201-24-3.mol
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ReMogliflozin etabonate Property

Boiling point:
661.3±55.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: Soluble; Methanol: Soluble
form 
A solid
pka
12.58±0.70(Predicted)
color 
White to off-white
InChIKey
UAOCLDQAQNNEAX-JJJFNNNPNA-N
SMILES
O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)OCC)O1)O)C1=NN(C(C)C)C(C)=C1CC1C=CC(OC(C)C)=CC=1 |&1:1,2,3,5,7,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14341
Product name
Remogliflozin etabonate
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
14341
Product name
Remogliflozin etabonate
Packaging
5mg
Price
$543
Updated
2024/03/01
ChemScene
Product number
CS-0003650
Product name
Remogliflozinetabonate
Purity
99.43%
Packaging
5mg
Price
$425
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009699
Product name
REMOGLIFLOZIN ETABONATE
Purity
95.00%
Packaging
5MG
Price
$502.54
Updated
2021/12/16
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ReMogliflozin etabonate Chemical Properties,Usage,Production

Uses

Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models[1].

Definition

ChEBI: Remogliflozin etabonate is a glycoside.

Synthesis

Synthesis of ReMogliflozin etabonate

in vivo

Remogliflozin etabonate (GSK189075; 10 or 30 mg/kg; orally; twice daily for 6 weeks) significantly reduced both the FPG and GHb levels in a dosedependent manner[1].
Remogliflozin etabonate (3, 10, 30 mg/kg; orally) increases urinary glucose excretion in a dose-dependent manner. Remogliflozin etabonate dose-dependently inhibits the increase in plasma glucose after glucose loading and decreases the plasma insulin in normal rats[1].
Remogliflozin etabonate (1-10 mg/kg; orally) decreases the blood glucose and reduces the AUC0–6 h for blood glucose in a dose-dependent manner[1].
Remogliflozin etabonate (high-fat diet containing 0.01, 0.03, or 0.1% remogliflozin etabonate for 8 weeks) reduces the levels of plasma glucose, plasma insulin, and GHb in a dose-dependent manner, and it suppresses the development of hypertriglyceridemia in male GK rats (6 weeks of age)[1].

Animal Model:db/db mice at the age of 8 weeks[1]
Dosage:10 or 30 mg/kg
Administration:Orally; twice daily for 6 weeks
Result:Significantly reduced both the fasting plasma glucose (FPG) and glycated hemoglobin (GHb) levels in a dosedependent manner.
Reduced both urine volume and urinary glucose excretion with ameliorated the hyperglycemia.

IC 50

hSGLT2: 1.95 μM (Ki); rSGLT2: 2.14 μM (Ki); hSGLT1: 43.1 μM (Ki); rSGLT1: 8.57 μM (Ki)

References

[1] Yoshikazu Fujimori, et al. Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. J Pharmacol Exp Ther. 2008 Oct;327(1):268-76. DOI:10.1124/jpet.108.140210

ReMogliflozin etabonate Preparation Products And Raw materials

Raw materials

Preparation Products

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ReMogliflozin etabonate Suppliers

China 59 India 5 United States 6 Global 70
DoEasy Pharma Co., Ltd.
Tel
0571-0571-28806358 15397199029
Fax
0571-89057225
Email
songxy@doepharma.com
Country
China
ProdList
88
Advantage
55
Beijing Huikang Boyuan Chemical Tech Co., Ltd
Tel
010-68862197 13810598707
Fax
010-68882204
Email
sales@huikangchem.com
Country
China
ProdList
100
Advantage
61
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
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View Lastest Price from ReMogliflozin etabonate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
ReMogliflozin etabonate 442201-24-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29

442201-24-3, ReMogliflozin etabonateRelated Search:

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  • C26H38N2O9