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ReMogliflozin etabonate

Product Name
ReMogliflozin etabonate
CAS No.
442201-24-3
Chemical Name
ReMogliflozin etabonate
Synonyms
EOS-61714;GSK 189075;GSK189075A;GSK-189075A;GSK 189075A;ReMogliflozin etabonate;UAOCLDQAQNNEAX-ABMICEGHSA-N;Remogliflozin etabonate (GSK189075);Remogliflozin etabonate, 10 mM in DMSO;442201-24-3
CBNumber
CB72582855
Molecular Formula
C26H38N2O9
Formula Weight
522.6
MOL File
442201-24-3.mol
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ReMogliflozin etabonate Property

Boiling point:
661.3±55.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: Soluble; Methanol: Soluble
form 
A solid
pka
12.58±0.70(Predicted)
color 
White to off-white
InChIKey
UAOCLDQAQNNEAX-JJJFNNNPNA-N
SMILES
O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)OCC)O1)O)C1=NN(C(C)C)C(C)=C1CC1C=CC(OC(C)C)=CC=1 |&1:1,2,3,5,7,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14341
Product name
Remogliflozin etabonate
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
14341
Product name
Remogliflozin etabonate
Packaging
5mg
Price
$543
Updated
2024/03/01
ChemScene
Product number
CS-0003650
Product name
Remogliflozinetabonate
Purity
99.43%
Packaging
5mg
Price
$425
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009699
Product name
REMOGLIFLOZIN ETABONATE
Purity
95.00%
Packaging
5MG
Price
$502.54
Updated
2021/12/16
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ReMogliflozin etabonate Chemical Properties,Usage,Production

Uses

Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models[1].

Definition

ChEBI: Remogliflozin etabonate is a glycoside.

Synthesis

Synthesis of ReMogliflozin etabonate

in vivo

Remogliflozin etabonate (GSK189075; 10 or 30 mg/kg; orally; twice daily for 6 weeks) significantly reduced both the FPG and GHb levels in a dosedependent manner[1].
Remogliflozin etabonate (3, 10, 30 mg/kg; orally) increases urinary glucose excretion in a dose-dependent manner. Remogliflozin etabonate dose-dependently inhibits the increase in plasma glucose after glucose loading and decreases the plasma insulin in normal rats[1].
Remogliflozin etabonate (1-10 mg/kg; orally) decreases the blood glucose and reduces the AUC0–6 h for blood glucose in a dose-dependent manner[1].
Remogliflozin etabonate (high-fat diet containing 0.01, 0.03, or 0.1% remogliflozin etabonate for 8 weeks) reduces the levels of plasma glucose, plasma insulin, and GHb in a dose-dependent manner, and it suppresses the development of hypertriglyceridemia in male GK rats (6 weeks of age)[1].

Animal Model:db/db mice at the age of 8 weeks[1]
Dosage:10 or 30 mg/kg
Administration:Orally; twice daily for 6 weeks
Result:Significantly reduced both the fasting plasma glucose (FPG) and glycated hemoglobin (GHb) levels in a dosedependent manner.
Reduced both urine volume and urinary glucose excretion with ameliorated the hyperglycemia.

IC 50

hSGLT2: 1.95 μM (Ki); rSGLT2: 2.14 μM (Ki); hSGLT1: 43.1 μM (Ki); rSGLT1: 8.57 μM (Ki)

References

[1] Yoshikazu Fujimori, et al. Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. J Pharmacol Exp Ther. 2008 Oct;327(1):268-76. DOI:10.1124/jpet.108.140210

ReMogliflozin etabonate Preparation Products And Raw materials

Raw materials

Preparation Products

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ReMogliflozin etabonate Suppliers

China 57 India 5 United States 6 Global 68
DoEasy Pharma Co., Ltd.
Tel
0571-0571-28806358 15397199029
Fax
0571-89057225
Email
songxy@doepharma.com
Country
China
ProdList
82
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
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View Lastest Price from ReMogliflozin etabonate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
ReMogliflozin etabonate 442201-24-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29

442201-24-3, ReMogliflozin etabonateRelated Search:

Repaglinide

  • ReMogliflozin etabonate
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  • ethyl(((2R,3S,4S,5R,6S)-6-((4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1H-pyrazol-3-yl)oxy)-3,4,5-tri(l1-oxidanyl)tetrahydro-2H-pyran-2-yl)methyl)carbonateGSK-189075
  • EOS-61714
  • UAOCLDQAQNNEAX-ABMICEGHSA-N
  • β-D-Glucopyranoside, 5-methyl-4-[[4-(1-methylethoxy)phenyl]methyl]-1-(1-methylethyl)-1H-pyrazol-3-yl, 6-(ethyl carbonate)
  • GSK 189075A
  • GSK189075A
  • GSK-189075A
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  • Remogliflozin etabonate (GSK189075)
  • Ethyl (((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((4-(4-isopropoxybenzyl)-1-isopropyl-5-Methyl-1H-pyrazol-3-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl) carbonate
  • Remogliflozin etabonate, 10 mM in DMSO
  • 442201-24-3
  • C26H38N2O9