(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone

Product Name: (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone
CAS No.: 147254-64-6
Chemical Name: (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone
Synonyms: AS-3201;AS 3201;SX-3201;Raniestat;Ranirestat;AS-3201; SX-3201;Ranirestat,AS-3201;Ranirestat >=97% (HPLC);(R)-2'-(4-bromo-2-fluorobenzyl)-1'H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone;(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone
CBNumber: CB72589748
Molecular Formula: C17H11BrFN3O4
Formula Weight: 420.19
MOL File: 147254-64-6.mol

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(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Property

Melting point:: 192-193℃
Boiling point:: 702.7±60.0 °C(Predicted)
Density: 1.83
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: 20mg/mL, clear
form: Solid
pka: 10.48±0.20(Predicted)
color: Off-white to pink
optical activity: [α]/D -5 to -10°, c =1.0 in methanol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: R119950
Product name: Ranirestat
Packaging: 5mg
Price: $115
Updated: 2021/12/16

TRC

Product number: R119950
Product name: Ranirestat
Packaging: 10mg
Price: $220
Updated: 2021/12/16

TRC

Product number: R119950
Product name: Ranirestat
Packaging: 50mg
Price: $860
Updated: 2021/12/16

ChemScene

Product number: CS-4282
Product name: Ranirestat
Purity: 98.32%
Packaging: 10mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-4282
Product name: Ranirestat
Purity: 98.32%
Packaging: 5mg
Price: $312
Updated: 2021/12/16

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(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Chemical Properties,Usage,Production

Uses

Ranirestat is an aldose reductase inhibitor used for the treatment of diabetic sensorimotor polyneuropathy.

Biological Activity

Ranirest at (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirest at has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirest at prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Suppliers

China 25 United States 8 Global 33

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147254-64-6, (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraoneRelated Search:

AS-3201; SX-3201

SX-3201

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone

Ranirestat

AS 3201

AS-3201

Spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone,2'-[(4-broMo-2-fluorophenyl)Methyl]-, (3R)-

Ranirestat,AS-3201

Raniestat

Ranirestat >=97% (HPLC)

(R)-2'-(4-bromo-2-fluorobenzyl)-1'H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone

147254-64-6

C17H11BrFN3O4