(R)-MG132

ChemicalBook > CAS DataBase List > (R)-MG132

Product Name: (R)-MG132
CAS No.: 1211877-36-9
Chemical Name: (R)-MG132
Synonyms: D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-;NSC60585;NSC 60585;MG-132(R);(R)-MG132;NSC-60585;MG-132(S,R,S);Z-Leu-D-leu-leu-al;(S,R,S)-(-)-MG-132;Cbz-L-leu-D-leu-L-leu-H
CBNumber: CB72589829
Molecular Formula: C26H41N3O5
Formula Weight: 475.62
MOL File: 1211877-36-9.mol

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(R)-MG132 Property

Boiling point:: 682.0±55.0 °C(Predicted)
Density: 1.073±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
pka: 11.14±0.46(Predicted)
form: powder

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1135
Product name: MG-132(R)
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $482
Updated: 2024/03/01

Sigma-Aldrich

Product number: M8699
Product name: (R)-MG132
Packaging: 1MG
Price: $180
Updated: 2023/06/20

Cayman Chemical

Product number: 13697
Product name: (R)-MG132
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 13697
Product name: (R)-MG132
Purity: ≥98%
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 13697
Product name: (R)-MG132
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

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(R)-MG132 Chemical Properties,Usage,Production

Description

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC₅₀s = 0.22 versus 0.89 μM (ChTL); 34.4 versus 104.43 μM (TL); 2.95 versus 5.70 μM (PGPH), respectively).

Uses

(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.

Uses

(R)-MG-132 is a potent, reversible and selective tripeptide aldehyde proteasome inhibitor.

Definition

ChEBI: D-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]- is a peptide.

Biochem/physiol Actions

MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.

storage

Store at -20°C

(R)-MG132 Preparation Products And Raw materials

Raw materials

Preparation Products

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1211877-36-9, (R)-MG132Related Search:

N-ACETYLLACTOSAMINE Dodecyl acrylate 5-METHYL-N,N-DIMETHYLTRYPTAMINE N-Methoxyphthalimide

(R)-MG132

Cbz-L-leu-D-leu-L-leu-H

N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide

MG-132(R)

benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

MG-132(S,R,S)

(S,R,S)-(-)-MG-132

Z-Leu-D-leu-leu-al

D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-

N-benzyloxycarbonyl-L-leucyl-D-leucyl-L-leucinal

NSC 60585

NSC60585

NSC-60585

Benzyl ((S)-1-(((R)-1-amino-4-methyl-1-oxopentan-2-yl)((S)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

1211877-36-9

peptides