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BIX01294 (hydrochloride hydrate)

Product Name
BIX01294 (hydrochloride hydrate)
CAS No.
1808255-64-2
Chemical Name
BIX01294 (hydrochloride hydrate)
Synonyms
BIX01294 (hydrochloride hydrate);BIX01294 (hydrochloride hydrate),BIX-01294 (hydrochloride hydrate);N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrate trihydrochloride;2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
CBNumber
CB72590339
Molecular Formula
C28H41ClN6O3
Formula Weight
545.13
MOL File
1808255-64-2.mol
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BIX01294 (hydrochloride hydrate) Property

storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/ml; Water: 10 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
1mg
Price
$30
Updated
2024/03/01
Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
5mg
Price
$113
Updated
2024/03/01
Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
13124
Product name
BIX01294 (hydrochloride hydrate)
Purity
≥98%
Packaging
50mg
Price
$558
Updated
2024/03/01
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BIX01294 (hydrochloride hydrate) Chemical Properties,Usage,Production

Description

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.1,2,3 BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM).4 It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases.4 BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.5

Uses

BIX-01294 hydrochloride hydrate is a histone-lysine methyltransferase (HMTase) inhibitor, which selective inhibits the G9aHMTase with IC50 of 1.7 μM, reduces histone-3 lysine (9) methylation (H3K9me), induces autophagy and apoptosis in human glioma cells[1][2].

IC 50

G9a: 1.7 μM (IC50); GLP: 38 μM (IC50)

References

1. Tachibana, M., Sugimoto, K., Nozaki, M., et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis Genes Dev. 16(14),1779-1791(2002).
2. Wagschal, A., Sutherland, H.G., Woodfine, K., et al. G9a histone methyltransferase contributes to imprinting in the mouse placenta Mol. Cell Biol. 28(3),1104-1113(2008).
3. Thomas, L.R., Miyashita, H., Cobb, R.M., et al. Functional analysis of histone methyltransferase G9a in B and T lymphocytes J. Immunol. 181(1),485-493(2008).
4. Kubicek, S., O'Sullivan, R.J., August, E.M., et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase Mol. Cell 25,473-481(2007).
5. Shi, Y., Desponts, C., Do, J.T., et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds Cell Stem Cell 3(5),568-574(2008).

BIX01294 (hydrochloride hydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX01294 (hydrochloride hydrate) Suppliers

China 27 United States 5 Global 32
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd
Tel
15658004993
Email
1900830611@qq.com
Country
China
ProdList
980
Advantage
58
NewCan Biotech Limited
Tel
+86-0571-86912261 +86-15658003402
Fax
311113
Email
sales@newcanbio.com
Country
China
ProdList
1390
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58

1808255-64-2, BIX01294 (hydrochloride hydrate)Related Search:


  • BIX01294 (hydrochloride hydrate)
  • BIX01294 (hydrochloride hydrate),BIX-01294 (hydrochloride hydrate)
  • 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
  • N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrate trihydrochloride
  • 1808255-64-2