CAY10416

Product Name: CAY10416
CAS No.: 443919-96-8
Chemical Name: CAY10416
Synonyms: CAY10416;COX-25-LOX-IN-4;CAY10416,CAY-10416;3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole;1H-Pyrazole, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-
CBNumber: CB72590410
Molecular Formula: C29H29FN2O5S
Formula Weight: 536.61
MOL File: 443919-96-8.mol

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CAY10416 Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70635
Product name: CAY10416
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 70635
Product name: CAY10416
Purity: ≥95%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 70635
Product name: CAY10416
Purity: ≥95%
Packaging: 10mg
Price: $437
Updated: 2024/03/01

TRC

Product number: B434815
Product name: 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
Packaging: 2.5mg
Price: $155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000699
Product name: 3-[[3-FLUORO-5-(TETRAHYDRO-4-METHOXY-2H-PYRAN-4-YL)PHENOXY]METHYL]-1-[4-(METHYLSULFONYL)PHENYL]-5-PHENYL-1H-PYRAZOLE
Purity: 95.00%
Packaging: 1MG
Price: $160.65
Updated: 2021/12/16

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CAY10416 Chemical Properties,Usage,Production

Description

Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC₅₀ values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 μM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC₅₀ value of 83 μM.

Uses

3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole is a dual inhibitor of Cox-2 and 5-LO.

References

[1] SABINE BARBEY . Synthesis and Activity of a New Methoxytetrahydropyran Derivative as Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitor[J]. Bioorganic & Medicinal Chemistry Letters, 2002, 12 5: Pages 779-782. DOI: 10.1016/s0960-894x(02)00013-6

CAY10416 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10416 Suppliers

Canada 1 China 23 United States 5 Global 29

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
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Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24960
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Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
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Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11972
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

443919-96-8, CAY10416Related Search:

CAY10416

3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole

1H-Pyrazole, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-

CAY10416,CAY-10416

COX-25-LOX-IN-4

443919-96-8

C29H29FN2O5S