ChemicalBook > CAS DataBase List > CAY10638

CAY10638

Product Name
CAY10638
CAS No.
1221413-57-5
Chemical Name
CAY10638
Synonyms
CAY10638;15-PGDH-IN-2;CAY10638 Exclusive;2,4-Thiazolidinedione, 5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]-
CBNumber
CB72590450
Molecular Formula
C16H13NO3S2
Formula Weight
331.41
MOL File
1221413-57-5.mol
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CAY10638 Property

solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 25 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13695
Product name
CAY10638
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
13695
Product name
CAY10638
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
13695
Product name
CAY10638
Purity
≥98%
Packaging
10mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
13695
Product name
CAY10638
Purity
≥98%
Packaging
25mg
Price
$456
Updated
2024/03/01
AK Scientific
Product number
3625DG
Product name
(5Z)-5-[[4-(2-Thiophen-2-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
Packaging
10mg
Price
$320
Updated
2021/12/16
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CAY10638 Chemical Properties,Usage,Production

Description

Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.1 Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.3

Uses

15-PGDH-IN-2 (Compound 2) is a 15-PGDH inhibitor with an IC50 value of 0.274 nM. 15-PGDH-IN-2 can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing[1].

Definition

ChEBI: CAY10638 is an aromatic ether.

References

1. Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review Prostaglandins 12(4),647-679(1976).
2. Owens, D.R. Thiazolidinediones. An pharmacological overview Clin. Drug Investig. 22(8),485-505(2002).
3. Wu, Y., Tai, H.H., and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors Bioorg. Med. Chem. 18,1428-1433(2010).

CAY10638 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10638 Suppliers

CHINA 24 United States 3 Global 27
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1221413-57-5, CAY10638Related Search:


  • CAY10638
  • CAY10638 Exclusive
  • 2,4-Thiazolidinedione, 5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]-
  • 15-PGDH-IN-2
  • 1221413-57-5