ChemicalBook > CAS DataBase List > GW 610

GW 610

Product Name: GW 610
CAS No.: 872726-44-8
Chemical Name: GW 610
Synonyms: GW 610;NSC 721648;NSC 721648 PMX 610;GW 610, 10 mM in DMSO;PMX 610 NSC 721648 W 610;NSC 721648 - CAS 872726-44-8 - Calbiochem;2-(3,4-Dimethoxyphenyl)-5-fluorobenzo[d]thiazole;Benzothiazole, 2-(3,4-dimethoxyphenyl)-5-fluoro-;GW 610,colon,Inhibitor,GW610,NSC721648,inhibit,breast,antitumor,NSC 721648,lung,GW-610,NSC-721648
CBNumber: CB72591189
Molecular Formula: C15H12FNO2S
Formula Weight: 289.3246832
MOL File: 872726-44-8.mol

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GW 610 Property

Melting point:: 110 °C
Boiling point:: 422.8±55.0 °C(Predicted)
Density: 1.293±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: DMF:10.0(Max Conc. mg/mL);34.56(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:9.5(Max Conc. mg/mL);32.84(Max Conc. mM)
form: White crystalline solid
pka: 0.73±0.10(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10008313
Product name: GW 610
Purity: ≥98%
Packaging: 1mg
Price: $22
Updated: 2024/03/01

Cayman Chemical

Product number: 10008313
Product name: GW 610
Purity: ≥98%
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 10008313
Product name: GW 610
Purity: ≥98%
Packaging: 10mg
Price: $167
Updated: 2024/03/01

Cayman Chemical

Product number: 10008313
Product name: GW 610
Purity: ≥98%
Packaging: 50mg
Price: $723
Updated: 2024/03/01

TRC

Product number: G929500
Product name: GW610
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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GW 610 Chemical Properties,Usage,Production

Description

GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI₅₀) < 0.1 nM) was observed. Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. In contrast with previously reported 2-(4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity.

Uses

GW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity.

References

[1] CATRIONA G. MORTIMER. Antitumor Benzothiazoles. 26.1 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory Activity against Lung, Colon, and Breast Cancer Cell Lines[J]. Journal of Medicinal Chemistry, 2005, 49 1: 179-185. DOI: 10.1021/jm050942k

GW 610 Preparation Products And Raw materials

Raw materials

Preparation Products

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872726-44-8, GW 610Related Search:

GW 610

NSC 721648

NSC 721648 - CAS 872726-44-8 - Calbiochem

NSC 721648 PMX 610

GW 610,colon,Inhibitor,GW610,NSC721648,inhibit,breast,antitumor,NSC 721648,lung,GW-610,NSC-721648

Benzothiazole, 2-(3,4-dimethoxyphenyl)-5-fluoro-

2-(3,4-Dimethoxyphenyl)-5-fluorobenzo[d]thiazole

PMX 610 NSC 721648 W 610

GW 610, 10 mM in DMSO

872726-44-8

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals