ChemicalBook > CAS DataBase List > Phthalazinone pyrazole

Phthalazinone pyrazole

Product Name
Phthalazinone pyrazole
CAS No.
880487-62-7
Chemical Name
Phthalazinone pyrazole
Synonyms
Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
CBNumber
CB72592005
Molecular Formula
C18H15N5O
Formula Weight
317.34
MOL File
880487-62-7.mol
More
Less

Phthalazinone pyrazole Property

Boiling point:
557.7±52.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO
form 
crystalline solid
pka
13.83±0.10(Predicted)
color 
Brown to gray
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
10735
Product name
Phthalazinone pyrazole
Purity
≥98%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
10735
Product name
Phthalazinone pyrazole
Purity
≥98%
Packaging
5mg
Price
$302
Updated
2024/03/01
Cayman Chemical
Product number
10735
Product name
Phthalazinone pyrazole
Purity
≥98%
Packaging
10mg
Price
$535
Updated
2024/03/01
ApexBio Technology
Product number
C3823
Product name
Phthalazinonepyrazole
Packaging
1mg
Price
$60
Updated
2021/12/16
ApexBio Technology
Product number
C3823
Product name
Phthalazinonepyrazole
Packaging
5mg
Price
$269
Updated
2021/12/16
More
Less

Phthalazinone pyrazole Chemical Properties,Usage,Production

Description

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).

in vitro

phthalazinone pyrazole potently inhibited the activity of aurora a kinase with an ic50 of 31 nm. it showed no inhibitory effect on aurora b kinase at doses up to 100 μm. phthalazinone pyrazole inhibited the proliferation of hct116, colo205, and mcf-7 cells with ic50 values of 7.8, 2.9, and 1.6 μm, respectively [1].

References

[1] prime m e, courtney s m, brookfield f a, et al. phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of aurora-a kinase[j]. journal of medicinal chemistry, 2010, 54(1): 312-319.
[2] vader g, lens s m a. the aurora kinase family in cell division and cancer[j]. biochimica et biophysica acta (bba)-reviews on cancer, 2008, 1786(1): 60-72.

Phthalazinone pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Phthalazinone pyrazole Suppliers

China 31 United States 3 Global 34
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4574
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7298
Advantage
58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
15502154572
Fax
-
Email
yuben012@sina.com
Country
China
ProdList
506
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4322
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3023
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb5@aikonchem.com
Country
China
ProdList
10526
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
4997
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9266
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32956
Advantage
60
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3135
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Haoran Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
470003480@QQ.COM
Country
CHINA
ProdList
6955
Advantage
58
Boao Pike
Tel
--
Fax
--
Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
Advantage
58
Shanghai Yaoyun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
912529879@qq.com
Country
CHINA
ProdList
6835
Advantage
58
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@neobioscience.com
Country
CHINA
ProdList
6151
Advantage
58
Resenbio
Tel
--
Fax
--
Email
sales@xarxbio.com
Country
China
ProdList
1774
Advantage
50
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6600
Advantage
58
Shanghai Jijin Chemical Technology Co., Ltd.
Tel
--
Fax
--
Email
jijinhuaxue@sina.com
Country
CHINA
ProdList
6606
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Shanghai Minmin Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1914109725@qq.com
Country
CHINA
ProdList
6518
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58

880487-62-7, Phthalazinone pyrazoleRelated Search:


  • Phthalazinone pyrazole
  • Phthalazinone pyrazole Exclusive
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one
  • 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-
  • 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one
  • Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one
  • 880487-62-7
  • 88048-62-7