1-Isopropylpyrazole-5-boronic Acid
Application- Product Name
- 1-Isopropylpyrazole-5-boronic Acid
- CAS No.
- 839714-33-9
- Chemical Name
- 1-Isopropylpyrazole-5-boronic Acid
- Synonyms
- 1-Isopropylpyrazole-5-boronic Acid;2-Isopropyl-2H-pyrazole-3-boronic acid;1-Isopropyl-1H-pyrazole-5-boronic acid;1-isopropyl-1H-pyrazol-5-ylboronic acid;(2-propan-2-ylpyrazol-3-yl)boronic acid;1-Isopropyl-1H-pyrazole-5-boronic acid 95+%;1-(1-methylethyl)-1H-pyrazol-5-yl]boronic acid;Boronic acid, [1-(1-methylethyl)-1H-pyrazol-5-yl]-;B-[1-(1-methylethyl)-1H-pyrazol-5-yl]-Boronic acid;Boronic acid, B-[1-(1-methylethyl)-1H-pyrazol-5-yl]-
- CBNumber
- CB72597590
- Molecular Formula
- C6H11BN2O2
- Formula Weight
- 153.97
- MOL File
- 839714-33-9.mol
1-Isopropylpyrazole-5-boronic Acid Property
- Boiling point:
- 312.0±34.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 8.02±0.58(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I873458
- Product name
- 1-Isopropyl-1H-pyrazole-5-boronicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 280762
- Product name
- 1-Isopropyl-1H-pyrazole-5-boronic acid
- Packaging
- 250mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- CS-B1110
- Product name
- Boronicacid,[1-(1-methylethyl)-1H-pyrazol-5-yl]-
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $86
- Updated
- 2021/12/16
- Product number
- CS-B1110
- Product name
- (1-Isopropyl-1H-pyrazol-5-yl)boronicacid
- Packaging
- 1g
- Price
- $86
- Updated
- 2021/12/16
- Product number
- CS-B1110
- Product name
- Boronicacid,[1-(1-methylethyl)-1H-pyrazol-5-yl]-
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $266
- Updated
- 2021/12/16
1-Isopropylpyrazole-5-boronic Acid Chemical Properties,Usage,Production
Application
1-Isopropylpyrazole-5-boronic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.
Synthesis
18952-87-9
839714-33-9
The general procedure for the synthesis of 1-isopropylpyrazole-5-boronic acid from 1-isopropylpyrazole was as follows: n-BuLi (17.46 g, 110 ml, 273 mM in hexane) was slowly added to a THF solution of 1-isopropyl-1H-pyrazole over a period of 30 min at -78 °C. The reaction mixture was stirred at -78 °C for 2 hours. Subsequently, a cooled solution of triisopropoxyborate (170.0 g, 909 mmol) was slowly added through a cannula over 45 minutes. The reaction mixture was slowly warmed from -50 °C to room temperature and stirred overnight. The pH of the reaction mixture was adjusted to 6-7 with 1 M HCl (170 mL). the solvent was evaporated to dryness and the resulting residue was ground with a 1:1 mixture of ethyl acetate:dichloromethane. The suspension was filtered and the solvent was evaporated in vacuo to give 1-isopropylpyrazole-5-boronic acid as a colorless solid (20.0 g, 58% yield).LCMS m/z (%) = 154 [M+H]+ (100).1H NMR (400 MHz, DMSO-d6) δ: 8.14 (s, 2H), 7.2 (s, 1H), 6.5 (s, 1H). 5.05 (m, 1H), 1.2 (d, J = 9.0Hz, 6H).
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1923 - 1936
[2] Patent: WO2005/12254, 2005, A1. Location in patent: Page/Page column 129
1-Isopropylpyrazole-5-boronic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Isopropylpyrazole-5-boronic Acid manufacturers
- Product
- 1-Isopropylpyrazole-5-boronic Acid 839714-33-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-05