4-broMo-5-Methoxy-1H-indazole
- Product Name
- 4-broMo-5-Methoxy-1H-indazole
- CAS No.
- 1192004-62-8
- Chemical Name
- 4-broMo-5-Methoxy-1H-indazole
- Synonyms
- 4-Bromo-5-methoxyindazole;4-broMo-5-Methoxy-1H-indazole;1H-Indazole, 4-bromo-5-methoxy-
- CBNumber
- CB72597848
- Molecular Formula
- C8H7BrN2O
- Formula Weight
- 227.06
- MOL File
- 1192004-62-8.mol
4-broMo-5-Methoxy-1H-indazole Property
- Boiling point:
- 363.4±22.0 °C(Predicted)
- Density
- 1.678±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.39±0.40(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679498
- Product name
- 4-Bromo-5-methoxy-1H-indazole
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B679498
- Product name
- 4-Bromo-5-methoxy-1H-indazole
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B679498
- Product name
- 4-Bromo-5-methoxy-1H-indazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CD11335021
- Product name
- 4-Bromo-5-methoxy-1H-indazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CD11335021
- Product name
- 4-Bromo-5-methoxy-1H-indazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $226
- Updated
- 2021/12/16
4-broMo-5-Methoxy-1H-indazole Chemical Properties,Usage,Production
Synthesis
29237-10-3
1192004-62-8
General procedure for the synthesis of 4-bromo-5-methoxy-1H-indazole from 3-bromo-4-methoxy-2-methylaniline: 1. 3-Bromo-4-methoxy-2-methylaniline (19.06 g) was dissolved in acetonitrile (250 mL), acetic anhydride (18.9 mL) was added slowly, and the reaction mixture was stirred for 1 hour at room temperature. 2. Potassium acetate (2.60 g) and amyl nitrite (22.3 g) were added to the reaction mixture and heated to reflux for 8 hours. 3. After completion of the reaction, the reaction mixture was concentrated and 6 M hydrochloric acid (200 mL) was added to the residue and heated to reflux overnight. 4. The reaction mixture was neutralized with 8 M sodium hydroxide and subsequently extracted with ethyl acetate. 5. The ethyl acetate layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. 6. The residue was dissolved in tetrahydrofuran, treated with activated charcoal, filtered to remove the activated charcoal and the filtrate was concentrated. 7. The residue was crystallized with diisopropyl ether, the crystals were collected by filtration, washed with diisopropyl ether and dried to obtain the target compound 4-bromo-5-methoxy-1H-indazole (10.42 g, yield 52%) as yellow crystals. Melting point: 178-180°C. Mass spectrum (MS): 229 (MH+).
References
[1] Patent: EP2266983, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: US2009/286800, 2009, A1. Location in patent: Page/Page column 109; 111
4-broMo-5-Methoxy-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
4-broMo-5-Methoxy-1H-indazole Suppliers
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