ChemicalBook > CAS DataBase List > N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide

N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide

Product Name
N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
CAS No.
1338247-35-0
Chemical Name
N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
Synonyms
LIMKI-3;CS-2190;BMS 5;BMS5;BMS-5 ≥95%;BMS-5 ，S0185;BMS-5， LIMKI-3;BMS-5, 10 mM in DMSO;LIMKI-3;BMS5;BMS 5;LIMKI3;LIMKI 3;LIMKi3,inhibit,LIM Kinase (LIMK),LIMKs,Inhibitor,BMS 5,BMS-5,LIMKi-3;N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
CBNumber
CB72598623
Molecular Formula
C17H14Cl2F2N4OS
Formula Weight
431.29
MOL File
1338247-35-0.mol
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N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide Property

Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO:PBS (pH 7.2) (1:5):0.2(Max Conc. mg/mL);0.46(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);6.96(Max Conc. mM)
pka
9.51±0.50(Predicted)
form 
White powder.
color 
White to off-white
InChI
1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)
InChIKey
IVUGBSGLHRJSSP-UHFFFAOYSA-N
SMILES
ClC1=CC=CC(Cl)=C1N2N=C(C=C2C3=CN=C(NC(C(C)C)=O)S3)C(F)F
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Safety

WGK Germany 
WGK 2
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
435930
Product name
LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem
Purity
The LIM Kinase Inhibitor I, LIMKi 3 controls the biological activity of LIM Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Packaging
10MG
Price
$297
Updated
2025/07/31
Cayman Chemical
Product number
21072
Product name
BMS-5
Purity
≥98%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
21072
Product name
BMS-5
Purity
≥98%
Packaging
5mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
21072
Product name
BMS-5
Purity
≥98%
Packaging
10mg
Price
$232
Updated
2024/03/01
Tocris
Product number
4745
Product name
LIMKi3
Purity
≥98%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
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N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide Chemical Properties,Usage,Production

Uses

LIMKi 3 is a LIM kinase 1 (LIMK1) inhibitor that has antitumor properties.

Definition

ChEBI: LimKi 3 is a member of the class of pyrazoles that is 1-(2,6-dichlorophenyl)-1H-pyrazole which is substituted by a difluoromethyl group at position 3 and by a 2-(isobutyrylamino)-1,3-thiazol-5-yl group at position 5. It is a a potent cell-permeable inhibitor of LIM kinase 1 and 2. It has a role as a LIM kinase inhibitor. It is a member of pyrazoles, a member of 1,3-thiazoles, a dichlorobenzene, an organofluorine compound and a secondary carboxamide.

Biological Activity

Cell permeable: yes', 'Primary Target
LIMK1 and LIMK2', 'Reversible: yes', 'Secondary Target
AMPKA1, AMPKA2, DDR1, PAK3, DCAMKL2', 'Target IC50: 7 and 8 nM against LIMK1 and LIMK2, respectively

in vivo

BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01)[3].

IC 50

LIMK1: 7 nM (IC50); LIMK2: 8 nM (IC50)

storage

Store at +4°C

N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide Suppliers

China 78 India 1 United Kingdom 2 United States 14 Global 95
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Shanghai Topbiochem Technology Co., Ltd
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021-58170097
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China
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Haoyuan Chemexpress Co., Ltd.
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(86) 21-58955996
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MedChemexpress LLC
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021-58955995
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Nanjing Dulai Biotechnology Co., Ltd.
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025-846993838003-8003 18013301590
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025-84699383-8003
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njduly@126.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Shanghaizehan biopharma technology co., Ltd.
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021-61350663 13052117465
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021-61350662
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sales@zehanbiopharma.com
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D&C Chemicals
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+86-21-58447131
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+86-21-61642470
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Guangzhou Zhiya Chemdrugs Co.,Ltd
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18122150900
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View Lastest Price from N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide manufacturers

Career Henan Chemical Co
Product
Mitoquinone mesylateN-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide 1338247-35-0
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

1338247-35-0, N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMideRelated Search:


  • N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
  • LIMKI-3
  • Mitoquinone mesylateN-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide
  • BMS-5， LIMKI-3
  • CS-2190
  • BMS-5 ≥95%
  • BMS 5;BMS5
  • N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide
  • N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
  • LIMKI-3;BMS5;BMS 5;LIMKI3;LIMKI 3
  • Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-
  • N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide[BMS5
  • LIMKi3,inhibit,LIM Kinase (LIMK),LIMKs,Inhibitor,BMS 5,BMS-5,LIMKi-3
  • BMS-5, 10 mM in DMSO
  • BMS-5 ，S0185
  • 1338247-35-0
  • C17H14Cl2F2N4OS