ChemicalBook > CAS DataBase List > (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide

(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide

Product Name
(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
CAS No.
66611-37-8
Chemical Name
(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
Synonyms
CS-2406;BGP-15 HCl;BGP-15 2HCl;BGP 15;BGP15;BGP-15 dihydrochloride;(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide;(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide;BGP-15,inhibit,BGP 15,Inhibitor,PARP,poly ADP ribose polymerase;N-(2-Hydroxy-3-(piperidin-1-yl)propoxy)-nicotinimidamide dihydrochloride;(Z)-N'-(2-Hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide dihydrochloride
CBNumber
CB72598850
Molecular Formula
C14H22N4O2
Formula Weight
278.35008
MOL File
66611-37-8.mol
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(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Property

storage temp. 
-20°C
solubility 
Soluble in Water (70 mg/ml)
form 
solid
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
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Safety

RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17503
Product name
BGP-15
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17503
Product name
BGP-15
Purity
≥95%
Packaging
5mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
17503
Product name
BGP-15
Purity
≥95%
Packaging
10mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
17503
Product name
BGP-15
Purity
≥95%
Packaging
25mg
Price
$530
Updated
2024/03/01
TRC
Product number
B411990
Product name
BGP15
Packaging
250mg
Price
$1010
Updated
2021/12/16
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(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Chemical Properties,Usage,Production

Description

BGP-15 (66611-37-8) is a cellular protectant operating by several mechanisms. It is an insulin sensitizer1, HSP72 activator2, PARP inhibitor and ROS and lipid peroxidation reducer3. It protects mitochondria in acetaminophen-induced liver injury4 as well as LPS-induced destabilization5 and activates mitochondrial fusion6. Displays protective effects in heart failure7 and traumatic brain injury8 in animal models.

Uses

BGP 15 is a calcipotriene-based vitamin D3 analog that inhibits poly(ADP-ribose) polymerasesis (PARP), a class of enzymes that regulate DNA repair and apoptosis (1). BGP 15 is also a cardioprotective agent (2). Also, BPG 15 improves mitochondrial function, protects neurons from dying in vitro and in vivo, and promotes cardiac innervation in vivo.

in vitro

previous study showed that bgp-15 at 200 μm could prevent the imatinib-induced oxidative damages, attenuate the depletion of high-energy phosphates, alter the signaling effect of imatinib by preventing p38 map kinase and jnk activation, and also induce the akt and gsk-3β phosphorylation [1].

in vivo

in-vivo study indicated that bgp-15 improved cardiac function and reduced arrhythmic episodes in two hf and af mouse models. in these models, bgp-15 was associated with increased phosphorylation of igf1r. moreover, cardiac-specific igf1r transgenic overexpression in mice recapitulated the protection caused by bgp-15. the authors further demonstrated that bgp-15 with igf1r could provide protection independent of phosphoinositide 3-kinase-akt and heat-shock protein 70 [2].

storage

Store at -20°C

References

Peto et al. (2020), Pharmacological Overview of the BGP-15 Chemical Agent as a New Drug Candidate for the Treatment of Symptoms of Metabolic Syndrome; Molecules 25 429 Henstridge et al. (2014), Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance; Diabetes 63 1881 Szabados et al. (2000), BGP-15, a nicotinic amidoxime derivative protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase; Biochem. Pharmacol. 59 937 Sarnyai et al. (2020), BGP-15 Protects Mitochondria in Acute Acetaminophen Overdose Induced Liver Injury; Pathol. Oncol. Res. 26 1797 Sumegi et al. (2017), BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species; PLos One 12 e0169372 Szabo et al. (2018), Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases; Biochem. Pharmacol. 150 86 Sapra et al. (2014), The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice; Nat. Commun. 5 5705 Eroglu et al. (2014), Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury; J. Neurochem. 130 626

(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Suppliers

Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
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55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4456
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55
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Fax
021-50426030
Email
2630597085@qq.com
Country
China
ProdList
1889
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4553
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8014
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
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68
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View Lastest Price from (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide manufacturers

Career Henan Chemical Co
Product
(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide 66611-37-8
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

66611-37-8, (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMideRelated Search:


  • CS-2406
  • BGP 15;BGP15
  • N-(2-Hydroxy-3-(piperidin-1-yl)propoxy)-nicotinimidamide dihydrochloride
  • BGP-15 HCl
  • (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
  • (Z)-N'-(2-Hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide dihydrochloride
  • BGP-15 2HCl
  • BGP-15 dihydrochloride
  • BGP-15,inhibit,BGP 15,Inhibitor,PARP,poly ADP ribose polymerase
  • (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
  • 66611-37-8
  • C14H24Cl2N4O2