ChemicalBook > CAS DataBase List > (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide

(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide

Product Name
(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
CAS No.
66611-37-8
Chemical Name
(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
Synonyms
B P-15;CS-2406;BGP-15 HCl;BGP-15 2HCl;BGP 15;BGP15;BGP-15 2HCl ，S8370;BGP-15, 10 mM in DMSO;BGP-15 dihydrochloride;(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide;BGP-15,inhibit,BGP 15,Inhibitor,PARP,poly ADP ribose polymerase
CBNumber
CB72598850
Molecular Formula
C14H22N4O2
Formula Weight
278.35008
MOL File
66611-37-8.mol
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(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Property

storage temp. 
-20°C
solubility 
Soluble in Water (70 mg/ml)
form 
solid
color 
Off-white
Water Solubility 
deionized water: 28mg/mL
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
InChI
1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H
InChIKey
ISGGVCWFTPTHIX-UHFFFAOYSA-N
SMILES
Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c2cccnc2
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Safety

RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Storage Class
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications
Acute Tox. 3 Oral
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B4813
Product name
BGP-15
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$192
Updated
2026/03/19
Sigma-Aldrich
Product number
B4813
Product name
BGP-15
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$771
Updated
2026/03/19
Cayman Chemical
Product number
17503
Product name
BGP-15
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17503
Product name
BGP-15
Purity
≥95%
Packaging
5mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
17503
Product name
BGP-15
Purity
≥95%
Packaging
10mg
Price
$249
Updated
2024/03/01
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(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Chemical Properties,Usage,Production

Description

BGP-15 (66611-37-8) is a cellular protectant operating by several mechanisms. It is an insulin sensitizer1, HSP72 activator2, PARP inhibitor and ROS and lipid peroxidation reducer3. It protects mitochondria in acetaminophen-induced liver injury4 as well as LPS-induced destabilization5 and activates mitochondrial fusion6. Displays protective effects in heart failure7 and traumatic brain injury8 in animal models.

Uses

BGP 15 is a calcipotriene-based vitamin D3 analog that inhibits poly(ADP-ribose) polymerasesis (PARP), a class of enzymes that regulate DNA repair and apoptosis (1). BGP 15 is also a cardioprotective agent (2). Also, BPG 15 improves mitochondrial function, protects neurons from dying in vitro and in vivo, and promotes cardiac innervation in vivo.

in vitro

previous study showed that bgp-15 at 200 μm could prevent the imatinib-induced oxidative damages, attenuate the depletion of high-energy phosphates, alter the signaling effect of imatinib by preventing p38 map kinase and jnk activation, and also induce the akt and gsk-3β phosphorylation [1].

in vivo

in-vivo study indicated that bgp-15 improved cardiac function and reduced arrhythmic episodes in two hf and af mouse models. in these models, bgp-15 was associated with increased phosphorylation of igf1r. moreover, cardiac-specific igf1r transgenic overexpression in mice recapitulated the protection caused by bgp-15. the authors further demonstrated that bgp-15 with igf1r could provide protection independent of phosphoinositide 3-kinase-akt and heat-shock protein 70 [2].

IC 50

PARP: 120 μM (IC50)

storage

Store at -20°C

References

[1] ÁGOTA PETŐ. Pharmacological Overview of the BGP-15 Chemical Agent as a New Drug Candidate for the Treatment of Symptoms of Metabolic Syndrome.[J]. Molecules, 2020, 25 2. DOI:10.3390/molecules25020429
[2] DARREN C HENSTRIDGE. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.[J]. ACS Applied Nano Materials, 2014: 1881-1894. DOI:10.2337/db13-0967
[3] ESZTER SZABADOS . BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase[J]. Biochemical pharmacology, 2000, 59 8: Pages 937-945. DOI:10.1016/s0006-2952(99)00418-9
[4] FARKAS SARNYAI. BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury[J]. Pathology & Oncology Research, 2019, 24 1: 1797-1803. DOI:10.1007/s12253-019-00721-1
[5] KATALIN SUMEGI. BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species[J]. PLoS ONE, 2017. DOI:10.1371/journal.pone.0169372
[6] ALIZ SZABO . Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases[J]. Biochemical pharmacology, 2018, 150: Pages 86-96. DOI:10.1016/j.bcp.2018.01.038
[7] GEETA SAPRA. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.[J]. Nature Communications, 2014: 5705. DOI:10.1038/ncomms6705
[8] BINNUR EROGLU. Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury[J]. Journal of Neurochemistry, 2014, 130 5: 626-641. DOI:10.1111/jnc.12781

(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide Suppliers

China 75 United States 13 Global 88
Suzhou Shentuo Pharmaceutical Technology Co., Ltd
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13911244683 18151949202
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info@visonpharma.com
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17714375163
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
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China
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SynAsst Chemical.
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021-60343070
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021-35122006
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China
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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isunpharm@qq.com
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China
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Bide Pharmatech Ltd.
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400-400-164-7117 18317119277
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+86-21-61629029
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Tongling HengYou Biotechnology Co., Ltd.
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021-50426030 13856289449
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021-50426030
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2630597085@qq.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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View Lastest Price from (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide manufacturers

Career Henan Chemical Co
Product
(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide 66611-37-8
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

66611-37-8, (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMideRelated Search:

Simvastatin N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Cilostazol IWP-2

  • CS-2406
  • BGP 15;BGP15
  • N-(2-Hydroxy-3-(piperidin-1-yl)propoxy)-nicotinimidamide dihydrochloride
  • BGP-15 HCl
  • (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide
  • (Z)-N'-(2-Hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide dihydrochloride
  • BGP-15 2HCl
  • BGP-15 dihydrochloride
  • BGP-15,inhibit,BGP 15,Inhibitor,PARP,poly ADP ribose polymerase
  • B P-15
  • BGP-15, 10 mM in DMSO
  • BGP-15 2HCl ，S8370
  • 66611-37-8
  • C14H24Cl2N4O2