ChemicalBook > CAS DataBase List > 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide

Product Name
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
CAS No.
1012104-68-5
Chemical Name
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
Synonyms
IRAK inhibitor 4;1H-BenziMidazole-5-carboxaMide, 1-(4-hydroxycyclohexyl)-N-(3-Methylbutyl)-2-[[5-[2-(trifluoroMethoxy)phenyl]-1H-indazol-3-yl]aMino]-;1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide;1-((1R, 4R)-4-Hydroxycyclohexyl)-N-isopentyl-2-(5-(2-(trifluoromethoxy)phenyl)-1H-indazol-3-ylamino)-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
CBNumber
CB72604243
Molecular Formula
C33H35F3N6O3
Formula Weight
620.66
MOL File
1012104-68-5.mol
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1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Property

Density 
1.41
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
13.54±0.40(Predicted)
color 
Off-white to light brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A3503
Product name
IRAKinhibitor4
Packaging
2mg
Price
$704
Updated
2021/12/16
ChemScene
Product number
CS-0606
Product name
IRAKinhibitor4
Purity
99.77%
Packaging
5mg
Price
$804
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001409
Product name
1-((1R,4R)-4-HYDROXYCYCLOHEXYL)-N-ISOPENTYL-2-(5-(2-(TRIFLUOROMETHOXY)PHENYL)-1H-INDAZOL-3-YLAMINO)-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID (3-METHYLBUTYL)AMIDE
Purity
95.00%
Packaging
5MG
Price
$1162.7
Updated
2021/12/16
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1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Chemical Properties,Usage,Production

Biological Activity

irak inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].irak-4 belongs to interleukin-1 receptor-associated kinase, which are key components in the signal transduction pathways. irak-4 is an essential signal transducer downstream of interleukin-1 receptor (il-1r), interleukin-18 receptor (il-18r) and toll-like receptors (tlrs). inhibition of irak-4 can modulate its function, thus toning down inflammatory responses. irak inhibitor 4 is an indazole inhibitor. as inhibitors of irak-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1].

target

IRAK

References

[1] zhulun wang, holger wesche, tracey stevens, nigel walker and wen-chen yeh. irak-4 inhibitors for inflammation. current topics in medicinal chemistry. 2009, 9: 724-737.

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Suppliers

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1012104-68-5, 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amideRelated Search:


  • 1-((1R, 4R)-4-Hydroxycyclohexyl)-N-isopentyl-2-(5-(2-(trifluoromethoxy)phenyl)-1H-indazol-3-ylamino)-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
  • 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
  • IRAK inhibitor 4
  • 1H-BenziMidazole-5-carboxaMide, 1-(4-hydroxycyclohexyl)-N-(3-Methylbutyl)-2-[[5-[2-(trifluoroMethoxy)phenyl]-1H-indazol-3-yl]aMino]-
  • 1012104-68-5
  • C33H35F3N6O3