Ethyl 7-chloroindole-2-carboxylate
- Product Name
- Ethyl 7-chloroindole-2-carboxylate
- CAS No.
- 43142-64-9
- Chemical Name
- Ethyl 7-chloroindole-2-carboxylate
- Synonyms
- Ethyl 7-chloroindole-2-carboxylate;1H-Indole-2-carboxylic acid, 7-chloro-, ethyl ester
- CBNumber
- CB72604445
- Molecular Formula
- C11H10ClNO2
- Formula Weight
- 223.66
- MOL File
- 43142-64-9.mol
Ethyl 7-chloroindole-2-carboxylate Property
- Melting point:
- 105 °C
- Boiling point:
- 375.0±22.0 °C(Predicted)
- Density
- 1.329±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.43±0.30(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C11H10ClNO2/c1-2-15-11(14)9-6-7-4-3-5-8(12)10(7)13-9/h3-6,13H,2H2,1H3
- InChIKey
- HPDPSWAIDXFYTE-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2Cl)C=C1C(OCC)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E940765
- Product name
- Ethyl7-chloro-1H-indole-2-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- A269311
- Product name
- Ethyl7-chloro-1H-indole-2-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- CD11124651
- Product name
- Ethyl7-chloro-1H-indole-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- 43142649
- Product name
- Ethyl7-chloro-1H-indole-2-carboxylate
- Packaging
- 1g
- Price
- $178.5
- Updated
- 2021/12/16
- Product number
- CM245890
- Product name
- Ethyl7-chloro-1H-indole-2-carboxylate
- Purity
- 95%+
- Packaging
- 5g
- Price
- $368
- Updated
- 2021/12/16
Ethyl 7-chloroindole-2-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 7-chloroindole-2-carboxylate is an organic synthesis intermediate, mainly used in the synthesis of drugs and pesticide molecules containing indole rings, and is also an important component in chemical research.
Synthesis
115050-49-2
43142-64-9
General procedure for the synthesis of ethyl 7-chloro-1H-indole-2-carboxylate from the compound (CAS:115050-49-2): 500 g of polyphosphoric acid and 250 g of phosphoric acid were mixed, stirred and heated up to 90°C. Under stirring conditions, 65 g of phenylhydrazine 2-chlorophenylpyruvate pyruvic acid was slowly added and the temperature of the reaction was controlled to be between 90°C and 100°C. The reaction took about 1 hour. The dosing process takes about 1 hour. After completion of dosing, the reaction temperature was maintained to continue the reaction for 20 minutes and the reaction progress was monitored by TLC. Upon completion of the reaction, 1500 g of ice-water mixture was slowly added to quench the reaction and cooled to room temperature. The precipitate was collected by filtration, washed with water and dried to give a light yellow solid product. Upon drying, 51.3 g of ethyl 7-chloro-1H-indole-2-carboxylate was obtained in 85% yield.
References
[1] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0060; 0062
Ethyl 7-chloroindole-2-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Ethyl 7-chloroindole-2-carboxylate manufacturers
- Product
- Ethyl 7-chloroindole-2-carboxylate 43142-64-9
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-22