2-(4-broMophenyl)propanenitrile
- Product Name
- 2-(4-broMophenyl)propanenitrile
- CAS No.
- 42186-06-1
- Chemical Name
- 2-(4-broMophenyl)propanenitrile
- Synonyms
- 2-(4-broMophenyl)propanenitrile;2-(4-BroMo-phenyl)-propionitrile;Benzeneacetonitrile, 4-bromo-α-methyl-
- CBNumber
- CB72604591
- Molecular Formula
- C9H8BrN
- Formula Weight
- 210.07
- MOL File
- 42186-06-1.mol
2-(4-broMophenyl)propanenitrile Property
- Boiling point:
- 293.3±15.0 °C(Predicted)
- Density
- 1.409±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- colorless to light yellow liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B804245
- Product name
- 2-(4-bromophenyl)propanenitrile
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 5818AB
- Product name
- 2-(4-Bromophenyl)propanenitrile
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- HCH0360827
- Product name
- 2-(4-BROMOPHENYL)PROPANENITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.59
- Updated
- 2021/12/16
- Product number
- 5818AB
- Product name
- 2-(4-Bromophenyl)propanenitrile
- Packaging
- 10g
- Price
- $793
- Updated
- 2021/12/16
- Product number
- 143659
- Product name
- 2-(4-Bromophenyl)propanenitrile
- Purity
- 95%
- Packaging
- 5g
- Price
- $903
- Updated
- 2021/12/16
2-(4-broMophenyl)propanenitrile Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 42, p. 3114, 1977 DOI: 10.1021/jo00439a002
Synthesis
16532-79-9
74-88-4
42186-06-1
Example 649 Synthesis of 2-(4-bromophenyl)propionitrile: 2-(4-bromophenyl)acetonitrile (5.0 g, 25.5 mmol) was dissolved in anhydrous THF (70 mL) and cooled to 0°C. Sodium hydride (60 wt%, 1.5 g, 38.3 mmol) was added batchwise under stirring. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, methyl iodide (1.8 mL, 28.1 mmol) was added and stirring was continued for 14 hours. Upon completion of the reaction, the reaction was carefully quenched with water at 0 °C and diluted with ethyl acetate (200 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (silica gel, 0-30% ethyl acetate/heptane gradient elution) to afford the target product, 2-(4-bromophenyl)propionitrile (3.8 g, 72%), as a yellow oil.ESI MS m/z 210 [C9H8BrN + H]+.
References
[1] Journal of the American Chemical Society, 2015, vol. 137, # 19, p. 6156 - 6159
[2] Patent: WO2011/123419, 2011, A1. Location in patent: Page/Page column 386
[3] Patent: WO2017/139778, 2017, A1. Location in patent: Paragraph 00487
[4] Patent: US2013/331375, 2013, A1. Location in patent: Paragraph 0178
[5] Patent: WO2018/140876, 2018, A1. Location in patent: Page/Page column 113; 115
2-(4-broMophenyl)propanenitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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