2,4-dichloro-3-fluoropyridine
- Product Name
- 2,4-dichloro-3-fluoropyridine
- CAS No.
- 628691-85-0
- Chemical Name
- 2,4-dichloro-3-fluoropyridine
- Synonyms
- 2,4-dichloro-3-fluoropyridine;4,6-dichloro-3-fluoro-pyridine;Pyridine, 2,4-dichloro-3-fluoro-;2-chloro-3-fluoro-4-chloropyridine
- CBNumber
- CB72605972
- Molecular Formula
- C5H2Cl2FN
- Formula Weight
- 165.98
- MOL File
- 628691-85-0.mol
2,4-dichloro-3-fluoropyridine Property
- Boiling point:
- 187.7±35.0 °C(Predicted)
- Density
- 1.498±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.13±0.10(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D475935
- Product name
- 2,4-Dichloro-3-fluoropyridine
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- D475935
- Product name
- 2,4-Dichloro-3-fluoropyridine
- Packaging
- 1g
- Price
- $650
- Updated
- 2021/12/16
- Product number
- PC201271
- Product name
- 2,4-Dichloro-3-fluoropyridine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- PC201271
- Product name
- 2,4-Dichloro-3-fluoropyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- Z4967
- Product name
- 2,4-Dichloro-3-fluoropyridine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
2,4-dichloro-3-fluoropyridine Chemical Properties,Usage,Production
Uses
2,4-Dichloro-3-fluoropyridine is used in tthe preparation of (aza)indazolyl-aryl sulfonamide and related compounds for inhibiting GCN2 activity
Synthesis
17282-04-1
628691-85-0
1. a mixture of lithium diisopropylamide (2M in heptane/THF/ethylbenzene with 0.5% [w/w] LiBr stabilizer; 3.8 mL, 7.6 mmol) and THF (3 mL) was cooled to -78 °C under nitrogen protection. 2. a solution of 2-chloro-3-fluoropyridine (1.0 g, 7.6 mmol) in THF (2 mL) was added slowly dropwise for a controlled time of 1 minute. 3. After the reaction mixture was stirred at -78°C for 2 hours, a THF (3 mL) solution of hexachloroethane (2.0 g, 8.4 mmol) was added dropwise. 4. Stirring was continued at -78°C for 2 hr followed by quenching the reaction with saturated aqueous NH4Cl solution (20 mL). 5. The reaction mixture was extracted with EtOAc (100 mL) and the organic phase was dried with anhydrous MgSO4 and concentrated under reduced pressure. 6. The crude product was purified by silica gel column chromatography (eluent: 15% Et2O/isohexane) to afford 2,4-dichloro-3-fluoropyridine (795 mg, 63% yield). 7. converting 2,4-dichloro-3-fluoropyridine (495 mg, 3.0 mmol) to 7-chloro-8-fluoroimidazo[1,2-a]pyridine (225 mg, 44% yield) according to the method of Example 1. 8. brominating 7-chloro-8-fluoroimidazo[1,2-a]pyridine (115 mg, 0.67 mmol) according to the method of Example 1 to obtain 3-bromo-7-chloro-8-fluoroimidazo[1,2-a]pyridine (162 mg, 96% yield). 9. Reacting 3-bromo-7-chloro-8-fluoroimidazo[1,2-a]pyridine (45 mg, 0.18 mmol) with 4-fluoro-3-(pyridin-3-yl)phenylboronic acid (49 mg, 0.19 mmol) according to the method of Example 1 , the title compound was obtained as a white amorphous solid (49 mg, 80% yield).
References
[1] Patent: US2017/29404, 2017, A1. Location in patent: Paragraph 0102-0105
[2] Patent: WO2003/99816, 2003, A1. Location in patent: Page 51
2,4-dichloro-3-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-dichloro-3-fluoropyridine Suppliers
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- Country
- India
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View Lastest Price from 2,4-dichloro-3-fluoropyridine manufacturers
- Product
- 2,4-dichloro-3-fluoropyridine 628691-85-0
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%min
- Supply Ability
- 2000Kg
- Release date
- 2023-11-06
- Product
- 2,4-dichloro-3-fluoropyridine 628691-85-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-30