6,7-DiMethoxy-1-chloroisoquinoline

Product Name: 6,7-DiMethoxy-1-chloroisoquinoline
CAS No.: 21560-29-2
Chemical Name: 6,7-DiMethoxy-1-chloroisoquinoline
Synonyms: 1-chloro-6,7-diMethoxyisoquinoline;6,7-DiMethoxy-1-chloroisoquinoline;Isoquinoline, 1-chloro-6,7-dimethoxy-
CBNumber: CB72606191
Molecular Formula: C11H10ClNO2
Formula Weight: 223.66
MOL File: 21560-29-2.mol

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6,7-DiMethoxy-1-chloroisoquinoline Property

Melting point:: 155-160 °C
Boiling point:: 355.1±37.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.92±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C598378
Product name: 1-Chloro-6,7-dimethoxyisoquinoline
Packaging: 100mg
Price: $330
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141168
Product name: 1-Chloro-6,7-dimethoxyisoquinoline
Packaging: 50mg
Price: $74
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141168
Product name: 1-Chloro-6,7-dimethoxyisoquinoline
Packaging: 100mg
Price: $129
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141168
Product name: 1-Chloro-6,7-dimethoxyisoquinoline
Packaging: 250mg
Price: $257.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141168
Product name: 1-Chloro-6,7-dimethoxyisoquinoline
Packaging: 500mg
Price: $450
Updated: 2021/12/16

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6,7-DiMethoxy-1-chloroisoquinoline Chemical Properties,Usage,Production

Synthesis

16101-63-6

21560-29-2

General procedure for the synthesis of 1-chloro-6,7-dimethoxyisoquinolin-1(2H)-one from 6,7-dimethoxyisoquinolin-1(2H)-one: a mixed solution of 6,7-dimethoxyisoquinolin-1(2H)-one (200 mg, 0.97 mmol) and phosphorus trichloride (0.268 mL, 2.92 mmol) in acetonitrile (5 mL) was placed in a microwave reactor at 110 °C for 5 min with stirring. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate solution and stirring was continued for 1 h at room temperature. The reaction mixture was filtered through a diatomaceous earth pad and washed with ethyl acetate. The filtrate was concentrated to dryness under reduced pressure. The crude product was purified by fast column chromatography with the eluent being a solvent mixture of heptane and ethyl acetate (the ratio was tapered from 1:0 to 0:1) to afford the target product, 1-chloro-6,7-dimethoxyisoquinoline, as a gel (99 mg, 45.4% yield). Mass spectrometry analysis showed m/z 224.0 [M + H]+ (ESI).

References

[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 22, p. 6276 - 6279
[2] Angew. Chem., 2017, vol. 129, # 22, p. 6373 - 6376,4
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 14, p. 3199 - 3203
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 14, p. 3199 - 3203

6,7-DiMethoxy-1-chloroisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-DiMethoxy-1-chloroisoquinoline Suppliers

China 10 United Kingdom 1 Global 11

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21560-29-2, 6,7-DiMethoxy-1-chloroisoquinolineRelated Search:

6,7-DiMethoxy-1-chloroisoquinoline

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Isoquinoline, 1-chloro-6,7-dimethoxy-

21560-29-2