ChemicalBook > CAS DataBase List > 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

Product Name
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
CAS No.
865305-30-2
Chemical Name
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
Synonyms
Ro 4;AF 353;CS-2469;CHEMBL526307;AF-353 (Ro-4);AF-353, 10 mM in DMSO;CHEMBL526307;AF 353;AF353;5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine;Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353;5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
CBNumber
CB72609596
Molecular Formula
C14H17IN4O2
Formula Weight
400.21
MOL File
865305-30-2.mol
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2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Property

Boiling point:
510.2±60.0 °C(Predicted)
Density 
1.619±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 32 mg/mL (79.96 mM)
pka
6.89±0.10(Predicted)
form 
Solid
color 
Light brown to brown
InChI
InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)
InChIKey
AATPYXMXFBBKFO-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23034
Product name
AF-353
Packaging
1mg
Price
$32
Updated
2022/04/27
Cayman Chemical
Product number
23034
Product name
AF-353
Packaging
5mg
Price
$102
Updated
2022/04/27
Cayman Chemical
Product number
23034
Product name
AF-353
Packaging
10mg
Price
$189
Updated
2022/04/27
AK Scientific
Product number
1897CW
Product name
2,4-Pyrimidinediamine,5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-
Packaging
10mg
Price
$245
Updated
2021/12/16
ChemScene
Product number
CS-5061
Product name
AF-353
Purity
98.95%
Packaging
25mg
Price
$310
Updated
2021/12/16
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2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Chemical Properties,Usage,Production

Description

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.

Uses

AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].

in vivo

AF-353 (Ro-4) does not compromise oxygen levels or cardiac function[2].
AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) inhibits the purinergic response in both normal and spinal cord-injured (SCI) rats[2].
AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) also reduces the inter-contractile interval in normal but not in SCI rats; however, the frequency of non-voiding (NVC) in SCI rats is significantly reduced[2].

Animal Model:Female Sprague-Dawley rats (250–300 g) bearing SCI[2]
Dosage:10 mg/kg, 20 mg/kg
Administration:Intravenous injection; interval of 90 minutes, for 4 hours to 6 hours
Result:Significantly reduced purinergic response in both normal and SCI rats.

IC 50

P2X3 Receptor

References

[1] Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. DOI:10.1111/j.1476-5381.2010.00796.x
[2] Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414. DOI:10.1111/j.1464-410X.2012.11189.x

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Suppliers

China 71 India 1 United Kingdom 1 United States 9 Global 82
Shanghai Jinyin Biological Technology Co., Ltd
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021-20986266 18019349802
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814527417@qq.com
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China
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Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Changzhou Renaissance Chem Co. Ltd
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86-519-86202821
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Email： sales@rosewellchem.com
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China
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AdooQ Bioscience CHINA
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025-68650336
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Shanghai Lollane Biological Technology Co.,Ltd.
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+86-21-52996696
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Twochem Co.Ltd
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021-021-58111628 15800915896
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027-65388397 18164111589
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View Lastest Price from 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
af-353 865305-30-2
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-13
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
af-353 865305-30-2
Price
US $100.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-15

865305-30-2, 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-Related Search:


  • 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
  • AF 353
  • Ro 4
  • 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine
  • CHEMBL526307
  • CHEMBL526307;AF 353;AF353
  • CS-2469
  • 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride
  • 5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
  • AF-353 (Ro-4)
  • 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine
  • Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353
  • AF-353, 10 mM in DMSO
  • 865305-30-2
  • C14H17IN4O2
  • Inhibitors