7-cyanobenzo[b]thiophen-2-ylboronic acid

Product Name: 7-cyanobenzo[b]thiophen-2-ylboronic acid
CAS No.: 1119899-37-4
Chemical Name: 7-cyanobenzo[b]thiophen-2-ylboronic acid
Synonyms: 7-cyanobenzo[b]thiophen-2-ylboronic acid;B-(7-Cyanobenzo[b]thien-2-yl)boronic acid;Boronic acid, B-(7-cyanobenzo[b]thien-2-yl)-
CBNumber: CB72611023
Molecular Formula: C9H6BNO2S
Formula Weight: 203.03
MOL File: 1119899-37-4.mol

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7-cyanobenzo[b]thiophen-2-ylboronic acid Property

Boiling point:: 474.9±48.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 6.35±0.30(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0037456
Product name: (7-Cyanobenzo[b]thiophen-2-yl)boronicacid
Packaging: 100mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0037456
Product name: (7-Cyanobenzo[b]thiophen-2-yl)boronicacid
Packaging: 250mg
Price: $141
Updated: 2021/12/16

ChemScene

Product number: CS-0037456
Product name: (7-Cyanobenzo[b]thiophen-2-yl)boronicacid
Packaging: 1g
Price: $282
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0002603
Product name: 7-CYANOBENZO[B]THIOPHEN-2-YLBORONIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.6
Updated: 2021/12/16

ChemScene

Product number: CS-0037456
Product name: (7-Cyanobenzo[b]thiophen-2-yl)boronicacid
Packaging: 5g
Price: $845
Updated: 2021/12/16

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7-cyanobenzo[b]thiophen-2-ylboronic acid Chemical Properties,Usage,Production

Synthesis

22780-71-8

1119899-37-4

The general procedure for the synthesis of 7-cyanobenzo[b]thiophene-2-ylboronic acid using benzo[B]thiophene-7-carbonitrile as starting material was as follows: first, benzo[B]thiophene-7-carbonitrile (20 g, 0.126 mol) was dissolved in anhydrous THF (500 mL) under nitrogen protection. Subsequently, the reaction mixture was cooled to -90 °C in a liquid nitrogen bath and n-butyllithium (2.5 M hexane solution, 60 mL, 0.15 mol) was slowly added dropwise with continuous stirring. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -90 °C for 30 minutes. Next, trimethyl borate (26 g, 0.25 mol) was added to the reaction system and the reaction was continued at the same temperature for 30 minutes. Upon completion of the reaction, 2M HCl aqueous solution (300 mL) was added to neutralize the reaction mixture, at which point a solid precipitated. The mixture was continued to be stirred for 30 minutes and gradually warmed up to room temperature (about 30°C). Subsequently, the reaction mixture was poured into water (200 mL) and the precipitated solid was collected by filtration. Finally, the solid was washed with ice water and dried to give the target product 7-cyanobenzo[b]thiophen-2-ylboronic acid (18 g, 72% yield) as a white solid.

References

[1] Patent: WO2009/26345, 2009, A1. Location in patent: Page/Page column 45

7-cyanobenzo[b]thiophen-2-ylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1119899-37-4, 7-cyanobenzo[b]thiophen-2-ylboronic acidRelated Search:

7-cyanobenzo[b]thiophen-2-ylboronic acid

Boronic acid, B-(7-cyanobenzo[b]thien-2-yl)-

B-(7-Cyanobenzo[b]thien-2-yl)boronic acid

1119899-37-4

C9H6BNO2S