ChemicalBook > CAS DataBase List > 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid

4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid

Product Name
4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid
CAS No.
1006036-87-8
Chemical Name
4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid
Synonyms
MK-2894;MK 2894;MK2894;4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid;4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid;Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-
CBNumber
CB72614367
Molecular Formula
C25H22F3NO3S
Formula Weight
473.51
MOL File
1006036-87-8.mol
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4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid Property

Melting point:
254-256℃
Boiling point:
569.4±50.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
4.35±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0679
Product name
MK-2894
Purity
98.10%
Packaging
5mg
Price
$204
Updated
2021/12/16
ChemScene
Product number
CS-0679
Product name
MK-2894
Purity
98.10%
Packaging
10mg
Price
$343
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0014015
Product name
MK-2894
Purity
95.00%
Packaging
5MG
Price
$377.3
Updated
2021/12/16
ChemScene
Product number
CS-0679
Product name
MK-2894
Purity
98.10%
Packaging
50mg
Price
$1296
Updated
2021/12/16
DC Chemicals
Product number
DC9607
Product name
MK-2894
Purity
>98%
Packaging
250mg
Price
$2200
Updated
2021/12/16
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4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid Chemical Properties,Usage,Production

Biological Activity

mk-2894 is a highly potent and selective inhibitor of ep4 receptor with ic50 value of 2.5 nm [1].mk-2894 is a highly selective and potent second generation ep4 antagonist with a ki of 0.56±0.1nm in the radio ligand binding assay using membranes prepared from human ep1-4 overexpressed hek 293 cell lines. and the ep4 functional assay measures the inhibition of pge2-induced camp accumulation with ic50 of 2.5±0.7nm. in the aia model and gi tolerability model in male sd rats, mk-2894 shows a dose-dependent inhibition of pain response with ed50 of 0.36 mg/kg. it also has the potent activity in inhibiting chronic pawswelling with ed50 of 0.02 mg/kg/day. overall, mk-2894 displays the desired potency, selectivity, pharmacokinetic, and gi tolerability profile for further development and represents a potential safer alternative for treating pain and inflammation than traditional nsaids and coxibs [1].

target

EP4 receptor

References

[1] marc blouin, yongxin han, jason burch, julie farand, christophe mellon, mireille gaudreault, mark wrona, jean-francois levesque, danielle denis, marie-claude mathieu, rino stocco, erika vigneault, alex therien, patsy clark, steve rowland, daigen xu, gary o’neill, yves ducharme and rick friesen. the discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (mk-2894), a potent and selective prostaglandin e2 subtype 4 receptor antagonist. j. med. chem. 2010, 53: 2227–2238.

4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid Suppliers

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View Lastest Price from 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid manufacturers

Career Henan Chemical Co
Product
4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid 1006036-87-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-14

1006036-87-8, 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acidRelated Search:


  • 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid
  • MK-2894
  • 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid
  • MK 2894;MK2894
  • Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-
  • 1006036-87-8
  • C25H22F3NO3S