4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid

ChemicalBook > CAS DataBase List > 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid

4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid

Product Name: 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid
CAS No.: 1006036-87-8
Chemical Name: 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid
Synonyms: MK-2894;MK 2894;MK2894;4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid;4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid;Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-
CBNumber: CB72614367
Molecular Formula: C25H22F3NO3S
Formula Weight: 473.51
MOL File: 1006036-87-8.mol

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4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid Property

Melting point:: 254-256℃
Boiling point:: 569.4±50.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 4.35±0.10(Predicted)
color: White to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0679
Product name: MK-2894
Purity: 98.10%
Packaging: 5mg
Price: $204
Updated: 2021/12/16

ChemScene

Product number: CS-0679
Product name: MK-2894
Purity: 98.10%
Packaging: 10mg
Price: $343
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014015
Product name: MK-2894
Purity: 95.00%
Packaging: 5MG
Price: $377.3
Updated: 2021/12/16

ChemScene

Product number: CS-0679
Product name: MK-2894
Purity: 98.10%
Packaging: 50mg
Price: $1296
Updated: 2021/12/16

DC Chemicals

Product number: DC9607
Product name: MK-2894
Purity: >98%
Packaging: 250mg
Price: $2200
Updated: 2021/12/16

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4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid Chemical Properties,Usage,Production

Biological Activity

mk-2894 is a highly potent and selective inhibitor of ep4 receptor with ic50 value of 2.5 nm [1].mk-2894 is a highly selective and potent second generation ep4 antagonist with a ki of 0.56±0.1nm in the radio ligand binding assay using membranes prepared from human ep1-4 overexpressed hek 293 cell lines. and the ep4 functional assay measures the inhibition of pge2-induced camp accumulation with ic50 of 2.5±0.7nm. in the aia model and gi tolerability model in male sd rats, mk-2894 shows a dose-dependent inhibition of pain response with ed50 of 0.36 mg/kg. it also has the potent activity in inhibiting chronic pawswelling with ed50 of 0.02 mg/kg/day. overall, mk-2894 displays the desired potency, selectivity, pharmacokinetic, and gi tolerability profile for further development and represents a potential safer alternative for treating pain and inflammation than traditional nsaids and coxibs [1].

target

EP4 receptor

References

[1] marc blouin, yongxin han, jason burch, julie farand, christophe mellon, mireille gaudreault, mark wrona, jean-francois levesque, danielle denis, marie-claude mathieu, rino stocco, erika vigneault, alex therien, patsy clark, steve rowland, daigen xu, gary o’neill, yves ducharme and rick friesen. the discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (mk-2894), a potent and selective prostaglandin e2 subtype 4 receptor antagonist. j. med. chem. 2010, 53: 2227–2238.

4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid Preparation Products And Raw materials

Raw materials

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View Lastest Price from 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid manufacturers

Career Henan Chemical Co

Product: 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid 1006036-87-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-14

1006036-87-8, 4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acidRelated Search:

4-[1-[[[2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]benzoic acid

MK-2894

4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid

MK 2894;MK2894

Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-

1006036-87-8

C25H22F3NO3S