Difluoromethyl 2-pyridyl sulfone
- Product Name
- Difluoromethyl 2-pyridyl sulfone
- CAS No.
- 1219454-89-3
- Chemical Name
- Difluoromethyl 2-pyridyl sulfone
- Synonyms
- 2-PySO2CF2H;2-[(DifL;Hu Reagent;DFM-2-pyridyl sulfone;2-Pyridyl difluoromethyl sulfone;DifluoroMethyl 2-Pyridyl Sulfone;2-(Difluoromethanesulfonyl)pyridine;2-[(DifluoroMethyl)sulfonyl]pyridine;Pyridine, 2-[(difluoroMethyl)sulfonyl]-;Difluoromethyl 2-pyridyl sulfone 97% (HPLC)
- CBNumber
- CB72614473
- Molecular Formula
- C6H5F2NO2S
- Formula Weight
- 193.17
- MOL File
- 1219454-89-3.mol
Difluoromethyl 2-pyridyl sulfone Property
- Melting point:
- 47.0 to 51.0 °C
- Boiling point:
- 324.4±42.0 °C(Predicted)
- Density
- 1.423±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -2.60±0.19(Predicted)
- color
- Off-White
- BRN
- 20317604
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36
- Safety Statements
- 26-45-24/25
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 746061
- Product name
- Difluoromethyl 2-pyridyl sulfone
- Purity
- 97% (HPLC)
- Packaging
- 1g
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 746061
- Product name
- Difluoromethyl 2-pyridyl sulfone
- Purity
- 97% (HPLC)
- Packaging
- 5g
- Price
- $643
- Updated
- 2024/03/01
- Product number
- D5390
- Product name
- Difluoromethyl 2-Pyridyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $117
- Updated
- 2024/03/01
- Product number
- D446180
- Product name
- 2-[(Difluoromethyl)sulfonyl]pyridine
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- D446180
- Product name
- 2-[(Difluoromethyl)sulfonyl]pyridine
- Packaging
- 5g
- Price
- $255
- Updated
- 2021/12/16
Difluoromethyl 2-pyridyl sulfone Chemical Properties,Usage,Production
Description
Difluoromethyl 2-pyridyl sulfone, also known as Hu reagent, is a novel and efficient gem-difluoroolefination reagent for preparing gem-difluoroalkenes from both aldehydes and ketones. The fluorinated sulfinate intermediates during the gem-difluoroolefination is relatively stable, and can be halogenated in situ to afford bromo- and iododifluoromethyl compounds. It can also act as nucleophilic difluoro(sulfonato)methylation reagent for the synthesis of α,α-difluorosulfonates from aldehydes, and alkyl halides and triflates.
Uses
2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.
Uses
Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions. Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.
Reactions
(1) gem-Difluoroolefination of aldehydes and ketones.
(2) Halodifluoromethylation of aldehydes and ketones.
(3) (Fluorosulfonyl)difluoromethylation of aldehydes and ketones.
(4) Difluoro(sulfonato)methylation of alkyl halides and triflates.
(5) Aromatic difluoromethylation
General Description
Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.
References
[1] WENJUN MIAO. Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2021, 23 3: 711-715. DOI:10.1021/acs.orglett.0c03939.
[2] WENJUN MIAO. Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2016, 18 11: 2766-2769. DOI:10.1021/acs.orglett.6b01258.
[3] YANCHUAN ZHAO. Difluoromethyl 2-Pyridyl Sulfone: A New gem-Difluoroolefination Reagent for Aldehydes and Ketones[J]. Organic Letters, 2010, 12 7: 1444-1447. DOI:10.1021/ol100090r.
Difluoromethyl 2-pyridyl sulfone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Difluoromethyl 2-pyridyl sulfone manufacturers
- Product
- Difluoromethyl 2-pyridyl sulfone 1219454-89-3
- Price
- US $0.10-0.10/kg
- Min. Order
- 0.0005kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-15
- Product
- Pyridine, 2-[(difluoroMethyl)sulfonyl]- 1219454-89-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-16