Difluoromethyl 2-pyridyl sulfone

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Difluoromethyl 2-pyridyl sulfone

Product Name: Difluoromethyl 2-pyridyl sulfone
CAS No.: 1219454-89-3
Chemical Name: Difluoromethyl 2-pyridyl sulfone
Synonyms: 2-PySO2CF2H;2-[(DifL;Hu Reagent;DFM-2-pyridyl sulfone;2-Pyridyl difluoromethyl sulfone;DifluoroMethyl 2-Pyridyl Sulfone;2-(Difluoromethanesulfonyl)pyridine;2-[(DifluoroMethyl)sulfonyl]pyridine;Pyridine, 2-[(difluoroMethyl)sulfonyl]-;Difluoromethyl 2-pyridyl sulfone 97% (HPLC)
CBNumber: CB72614473
Molecular Formula: C6H5F2NO2S
Formula Weight: 193.17
MOL File: 1219454-89-3.mol

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Difluoromethyl 2-pyridyl sulfone Property

Melting point:: 47.0 to 51.0 °C
Boiling point:: 324.4±42.0 °C(Predicted)
Density: 1.423±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: -2.60±0.19(Predicted)
color: Off-White
BRN: 20317604

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45-24/25
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 746061
Product name: Difluoromethyl 2-pyridyl sulfone
Purity: 97% (HPLC)
Packaging: 1g
Price: $137
Updated: 2024/03/01

Sigma-Aldrich

Product number: 746061
Product name: Difluoromethyl 2-pyridyl sulfone
Purity: 97% (HPLC)
Packaging: 5g
Price: $643
Updated: 2024/03/01

TCI Chemical

Product number: D5390
Product name: Difluoromethyl 2-Pyridyl Sulfone
Purity: >98.0%(GC)
Packaging: 1g
Price: $117
Updated: 2024/03/01

TRC

Product number: D446180
Product name: 2-[(Difluoromethyl)sulfonyl]pyridine
Packaging: 1g
Price: $110
Updated: 2021/12/16

TRC

Product number: D446180
Product name: 2-[(Difluoromethyl)sulfonyl]pyridine
Packaging: 5g
Price: $255
Updated: 2021/12/16

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Difluoromethyl 2-pyridyl sulfone Chemical Properties,Usage,Production

Description

Difluoromethyl 2-pyridyl sulfone, also known as Hu reagent, is a novel and efficient gem-difluoroolefination reagent for preparing gem-difluoroalkenes from both aldehydes and ketones. The fluorinated sulfinate intermediates during the gem-difluoroolefination is relatively stable, and can be halogenated in situ to afford bromo- and iododifluoromethyl compounds. It can also act as nucleophilic difluoro(sulfonato)methylation reagent for the synthesis of α,α-difluorosulfonates from aldehydes, and alkyl halides and triflates.

Chemical Properties

Melting point 48-50°C, boiling point 324.4+42°C, relative density 1.423+0.06 g/cm³ , slightly soluble in water, casily soluble in acctonitrile and methanol.

Uses

Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions. Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.

Uses

2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.

Application

Difluoromethyl 2-pyridyl sulfone can be used for the introduction of difluoromethylene, as a difluoroalkylation reagent to reacwith aldehydes and ketones to prepare difluoroalkenesIt can be used for the introduction of difluoromethyl, reacting with aryl zine and aryl iodine to preparedifluoromethyl aryl compounds, and conducting free radical addition reactions with olefins.
It can be used as a nucleophilic difluoro (sulfonation) methylation reagent for synthesis from aldehydes.ketones, alkyl halides, trifluoromethanesulfonic acid esters, etc a,a- Difluoroalkyl sulfinates andsulfonates.
It can also be used together with electrophilic iodination reagents and bromination reagents for theintroduction ofmonoiododifluoromethyl and monobromodifluoromethyl groups.
It can also be used as a 2-pyridylation reagent.

Reactions

(1) gem-Difluoroolefination of aldehydes and ketones.

(2) Halodifluoromethylation of aldehydes and ketones.

(3) (Fluorosulfonyl)difluoromethylation of aldehydes and ketones.

(4) Difluoro(sulfonato)methylation of alkyl halides and triflates.

(5) Aromatic difluoromethylation

General Description

Difluoromethyl 2-pyridyl sulfone (2-PySO₂CF₂H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.

References

[1] WENJUN MIAO. Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2021, 23 3: 711-715. DOI:10.1021/acs.orglett.0c03939.
[2] WENJUN MIAO. Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2016, 18 11: 2766-2769. DOI:10.1021/acs.orglett.6b01258.
[3] YANCHUAN ZHAO. Difluoromethyl 2-Pyridyl Sulfone: A New gem-Difluoroolefination Reagent for Aldehydes and Ketones[J]. Organic Letters, 2010, 12 7: 1444-1447. DOI:10.1021/ol100090r.

Difluoromethyl 2-pyridyl sulfone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Difluoromethyl 2-pyridyl sulfone manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Difluoromethyl 2-pyridyl sulfone 1219454-89-3
Price: US $0.10/kg
Min. Order: 0.0005kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-04-15

Career Henan Chemical Co

Product: Pyridine, 2-[(difluoroMethyl)sulfonyl]- 1219454-89-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-16

1219454-89-3, Difluoromethyl 2-pyridyl sulfoneRelated Search:

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2-[(DifluoroMethyl)sulfonyl]pyridine

DifluoroMethyl 2-Pyridyl Sulfone

Difluoromethyl 2-pyridyl sulfone 97% (HPLC)

2-(Difluoromethanesulfonyl)pyridine

2-PySO2CF2H

Hu Reagent

2-[(DifL

DFM-2-pyridyl sulfone

2-Pyridyl difluoromethyl sulfone

1219454-89-3

Aromatics

Heterocycles

Sulfur & Selenium Compounds