A-770041

Product Name: A-770041
CAS No.: 869748-10-7
Chemical Name: A-770041
Synonyms: A-770041;selective,concanavalin A,inhibit,acute rejection,Src,IL-2,Inhibitor,T cell,rat,small-molecule,A 770041,A770041,A-770041;N-[4-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide;N-(4-(1-(trans-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide;N-[4-[1-[trans-4-(4-Acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide;1H-Indole-2-carboxamide, N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-;N-(4-(1-((1r,4r)-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide;N-(4-(1-(trans-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide?, A-770041
CBNumber: CB72627240
Molecular Formula: C34H39N9O3
Formula Weight: 621.73
MOL File: 869748-10-7.mol

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A-770041 Property

Boiling point:: 812.6±65.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M HCl: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
pka: 13.21±0.70(Predicted)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2678
Product name: A-770041
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $192.85
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2678
Product name: A-770041
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $533.4
Updated: 2025/07/31

ChemScene

Product number: CS-0057
Product name: A-770041
Purity: 99.53%
Packaging: 5mg
Price: $320
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001365
Product name: A-770041
Purity: 99.00%
Packaging: 5MG
Price: $320.1
Updated: 2021/12/16

Axon Medchem

Product number: Axon1698
Product name: A770041
Purity: 99%
Packaging: 25mg
Price: $495
Updated: 2021/12/16

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A-770041 Chemical Properties,Usage,Production

Uses

A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC50 value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection[1][2].

Definition

ChEBI: N-[4-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-3-pyrazolo[3,4-d]pyrimidinyl]-2-methoxyphenyl]-1-methyl-2-indolecarboxamide is an aromatic amide.

in vivo

A-770041 (2.5 mg/kg; i.g. once) inhibits concanavalin A-induced IL-2 in vivo^[1]. A-770041 (2.5-20 mg/kg/day; for 14 days) dose-dependently increases the survival rate with doses of 5 and 10 mg/kg/day, and survives 100% of transplanted grafts until 14 days with doses of 10 and 20 mg/kg/day^[1].

Animal Model:	Male Lewis rats^[1]
Dosage:	2.5 mg/kg
Administration:	Intragastric administration; 2.5 mg/kg once
Result:	Showed an inhibition of concanavalin A-induced IL-2 with an in vivo EC₅₀ value of 78 nM.

References

[1] Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41. DOI:10.1124/jpet.105.089169
[2] Andrew Burchat, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection Bioorganic & Medicinal Chemistry Letters Volume 16, Issue 1, 1 January 2006, Pages 118-122 DOI:10.1016/j.bmcl.2005.09.039

A-770041 Preparation Products And Raw materials

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A-770041 Suppliers

China 34 The Netherlands 1 United States 6 Global 41

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869748-10-7, A-770041Related Search:

A-770041

N-(4-(1-((1r,4r)-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

N-[4-[1-[trans-4-(4-Acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide

N-[4-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide

1H-Indole-2-carboxamide, N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-

selective,concanavalin A,inhibit,acute rejection,Src,IL-2,Inhibitor,T cell,rat,small-molecule,A 770041,A770041,A-770041

N-(4-(1-(trans-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

N-(4-(1-(trans-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide?, A-770041

869748-10-7

C34H39N9O3