ChemicalBook > CAS DataBase List > BNC105

BNC105

Product Name
BNC105
CAS No.
945771-74-4
Chemical Name
BNC105
Synonyms
BNC105;CS-2127;BNC105, 10 mM in DMSO;inhibit,Inhibitor,BNC 105,BNC105,BNC-105,Microtubule/Tubulin;6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-ol;2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan;(7-Hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone;Methanone, (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-
CBNumber
CB72627624
Molecular Formula
C20H20O7
Formula Weight
372.37
MOL File
945771-74-4.mol
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BNC105 Property

Melting point:
156-158 °C(Solv: methanol (67-56-1))
Boiling point:
529.3±50.0 °C(Predicted)
Density 
1.261±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:25.0(Max Conc. mg/mL);67.14(Max Conc. mM)
form 
A solid
pka
6.60±0.50(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-4191
Product name
BNC105
Purity
99.49%
Packaging
10mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-4191
Product name
BNC105
Purity
99.49%
Packaging
5mg
Price
$330
Updated
2021/12/16
Crysdot
Product number
CD31000118
Product name
BNC105
Purity
98+%
Packaging
10mg
Price
$347
Updated
2021/12/16
Crysdot
Product number
CD31000118
Product name
BNC105
Purity
98+%
Packaging
5mg
Price
$243
Updated
2021/12/16
Crysdot
Product number
CD31000118
Product name
BNC105
Purity
98+%
Packaging
50mg
Price
$1042
Updated
2021/12/16
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BNC105 Chemical Properties,Usage,Production

Uses

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

References

[1] Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. DOI:10.1021/jm200454y
[2] Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. DOI:10.1158/1535-7163.MCT-09-0815
[3] Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60. DOI:10.4161/15384047.2014.956605

BNC105 Preparation Products And Raw materials

Raw materials

Preparation Products

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945771-74-4, BNC105Related Search:


  • BNC105
  • 2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan
  • CS-2127
  • Methanone, (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-
  • (7-Hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone
  • inhibit,Inhibitor,BNC 105,BNC105,BNC-105,Microtubule/Tubulin
  • 6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-ol
  • BNC105, 10 mM in DMSO
  • 945771-74-4