ChemicalBook > CAS DataBase List > GSK 561679A

GSK 561679A

Product Name
GSK 561679A
CAS No.
885220-61-1
Chemical Name
GSK 561679A
Synonyms
CPD1230;CS-2618;NBI77860;GSK561679;Verucerfont;GSK 561679A;Verucerfont,GSK561679;Verucerfont/GSK561679A;Verucerfont, 10 mM in DMSO;VERUCERFONT; GSK561679; NBI77860
CBNumber
CB72627927
Molecular Formula
C22H26N6O2
Formula Weight
406.48
MOL File
885220-61-1.mol
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GSK 561679A Property

Density 
1.29
storage temp. 
Store at -20°C
solubility 
DMSO : 86.7 mg/mL (213.29 mM)
pka
4.78±0.40(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/s1
InChIKey
VKHVAUKFLBBZFJ-SFHVURJKSA-N
SMILES
C12=C(C3=CC=C(OC)C=C3C)C(C)=NN1C(N[C@H](C1ON=C(C)N=1)CC)=CC(C)=N2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
V125025
Product name
Verucerfont
Packaging
1mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-8099
Product name
Verucerfont
Purity
98.67%
Packaging
5mg
Price
$225
Updated
2021/12/16
ChemScene
Product number
CS-8099
Product name
Verucerfont
Purity
98.67%
Packaging
10mg
Price
$385
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013931
Product name
GSK-561679A
Purity
95.00%
Packaging
5MG
Price
$495.2
Updated
2021/12/16
ChemScene
Product number
CS-8099
Product name
Verucerfont
Purity
98.67%
Packaging
50mg
Price
$1150
Updated
2021/12/16
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GSK 561679A Chemical Properties,Usage,Production

Uses

Verucerfont, is a corticotropin-releasing factor receptor 1 (CRF1) antagonist.

in vivo

Post hoc analysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316?311, and pexacerfont (P<0.001 for all comparisons collapse across time-points); the latter three treatments in turn do not differ from each other. A differential effect of treatments over time is also shown by a significant treatment×time interaction (F[20,140]=6.4, P<0.001). Accordingly, detailed Post hoc analysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6?h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline)[1].

IC 50

CRFR1

GSK 561679A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK 561679A Suppliers

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885220-61-1, GSK 561679ARelated Search:


  • GSK 561679A
  • 3-(4-Methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a]pyrimidin-7-amine
  • Verucerfont
  • CPD1230
  • GSK561679
  • NBI77860
  • CS-2618
  • Verucerfont,GSK561679
  • VERUCERFONT; GSK561679; NBI77860
  • (S)-3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-(1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)pyrazolo[1,5-a]pyrimidin-7-amine
  • Pyrazolo[1,5-a]pyrimidin-7-amine, 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]-
  • GSK 561679,Verucerfont,Corticotropin-releasing Factor Receptor,Inhibitor,GSK-561679,CRFR,inhibit
  • Verucerfont/GSK561679A
  • Verucerfont, 10 mM in DMSO
  • 885220-61-1
  • C22H26N6O2