MarizoMib
- Product Name
- MarizoMib
- CAS No.
- 437742-34-2
- Chemical Name
- MarizoMib
- Synonyms
- SalinosporaMide A;Salinosporamide A (NPI-0052, Marizomib);ML 858;NPI 0052;MarizoMib;Marizomib (NPI 0052;(-)-SalinosporaMide A;Salinosporamide A (NPI-0052);Marizomib (Salinosporamide A);MarizoMib (NPI-0052, (-)-SalinosporaMide A)
- CBNumber
- CB72628070
- Molecular Formula
- C15H20ClNO4
- Formula Weight
- 313.78
- MOL File
- 437742-34-2.mol
MarizoMib Property
- Melting point:
- 168-170 °C
- Boiling point:
- 547.0±50.0 °C(Predicted)
- Density
- 1.348±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 13.10±0.20(Predicted)
- color
- white to beige
- optical activity
- -72.925 (methanol)
Safety
- RTECS
- RN6803500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1916
- Product name
- Marizomib
- Purity
- ≥95% (HPLC), (Salinospora tropica)
- Packaging
- 100μG
- Price
- $168
- Updated
- 2023/06/20
- Product number
- 10007311
- Product name
- Salinosporamide A
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- M197250
- Product name
- Marizomib
- Packaging
- 10mg
- Price
- $10080
- Updated
- 2021/12/16
- Product number
- 226808
- Product name
- Salinosporamide A
- Packaging
- 100ug
- Price
- $445
- Updated
- 2021/12/16
- Product number
- API0005308
- Product name
- MARIZOMIB
- Purity
- 95.00%
- Packaging
- 100μG
- Price
- $505.11
- Updated
- 2021/12/16
MarizoMib Chemical Properties,Usage,Production
Uses
Marizomib has been used as a proteasome inhibitor:
- to study its effects on glioblastoma cell lines
- to analyze its effects on the aging of killifish brain
- to test its effect on protein kinase B (PKB/AKT) levels in multiple myeloma cells
Definition
ChEBI: A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers.
Biological Activity
salinosporamide a is a potent inhibitor of 20s proteasome with ic50 value of 1.3 nm [1].salinosporamide a was isolated from the crude extract of a salinospora strain cnb-392. it showed potent anti-tumor activity with an ic50 value of 11 ng/ml in hct-116 cells. it also exerted a mean gi50 value of less than 10 nm in the nci’s 60 cell line-panel. among these cell lines, salinosporamide a showed the greatest potent efficacies in nci-h226, sf-539, sk-mel-28 and mda-mb-435 cells. salinosporamide a inhibited the purified 20s proteasome with ic50 value of 1.3 nm. it was about 35-fold more potent than the first discovered specific proteasome inhibitor, omuralide [1].
Biochem/physiol Actions
Marizomib is a second generation proteasome inhibitor with anti-cancer activity. Marizomib binds irreversibly and potently inhibits all three 20S proteasome subunits.
target
CT-L (EC50）
References
[1] feling r h, buchanan g o, mincer t j, et al. salinosporamide a: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. angewandte chemie international edition, 2003, 42(3): 355-357.
MarizoMib Preparation Products And Raw materials
Raw materials
Preparation Products
MarizoMib Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
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- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
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- Country
- United States
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- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
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- 19553
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- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
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- United States
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- tony@proactivemr.com
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- United States
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- United States
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- Tel
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- chemicals@usbio.net
- Country
- United States
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View Lastest Price from MarizoMib manufacturers
- Product
- MarizoMib 437742-34-2
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 5kg ,50kg
- Release date
- 2020-01-08