MF498

Product Name: MF498
CAS No.: 915191-42-3
Chemical Name: MF498
Synonyms: MF498;CS-2084;MF498,MF-498;MF498;MF-498;MF 498;N-((4-(5,9-Diethoxy-6-oxo-6H-pyrrolo[3,4-g]quinolin-7(8H)-yl)-3-methylbenzyl)sulfonyl)-2-(2-me;Benzeneacetamide, N-[[[4-(5,9-diethoxy-6,8-dihydro-6-oxo-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methyl]sulfonyl]-2-methoxy-
CBNumber: CB72628131
Molecular Formula: C32H33N3O7S
Formula Weight: 603.69
MOL File: 915191-42-3.mol

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MF498 Property

Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid
pka: 3.85±0.40(Predicted)
color: Pink to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15973
Product name: MF498
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15973
Product name: MF498
Purity: ≥98%
Packaging: 5mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 15973
Product name: MF498
Purity: ≥98%
Packaging: 10mg
Price: $535
Updated: 2024/03/01

Cayman Chemical

Product number: 15973
Product name: MF498
Purity: ≥98%
Packaging: 25mg
Price: $1169
Updated: 2024/03/01

TRC

Product number: M340880
Product name: MF498
Packaging: 100mg
Price: $235
Updated: 2021/12/16

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MF498 Chemical Properties,Usage,Production

Uses

MF498 is a selective EP4, a Gs protein-coupled receptor, receptor antagonist. In HEK293 cells expressing the human EP4 receptor, MF498 inhibits E prostanoid (EP) ligand induced activity.

Biological Activity

mf498 is a novel and selective ep4 antagonist [1].prostaglandin e2 receptors (ep) are g-protein coupled receptors (gpcrs) and functions with the binding of prostaglandin (pg) e2. the eps exhibit differences in signal transduction, tissue localization, and regulation of expression. the ep4 receptor is over-expressed in human prostate cancer tissue [2].

in vitro

mf498 was a selective ep4 receptor antagonist with the ki of 0.7 nm while the ki > 1 μm for other ep receptors. in hek293 cells expressing human ep4 receptor, mf498 inhibited ep ligand-induced activity with an ic50 value of 1.7 nm [1].

in vivo

in rodent models of rheumatoid and osteoarthritis, mf498 inhibited inflammation without gastrointestinal toxicity, the ed50 values was as low as 0.02 mg/kg/day[1].in adjuvant-induced arthritis (aia) rat model for rheumatoid arthritis (ra), mf498 inhibited inflammation. in addition, mf498 was effective in relieving oa-like pain in guinea pigs. in rat models of gastrointestinal toxicity, mf498 was well tolerated, causing no mucosal leakage or erosions. in a furosemide-induced diuresis model, mf498 reduced furosemide-induced natriuresis by 50% [3].

References

[1] p. clark, s. e. rowland, d. denis, et al. mf498 [n-{[4-(5,9-diethoxy-6-oxo-6,8-dihydro-7h-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective e prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.journal of pharmacology and experimental therapeutics 325(2), 425-434 (2008).
[2] sugimoto y, narumiya s. prostaglandin e receptors[j]. journal of biological chemistry, 2007, 282(16): 11613-11617.
[3] clark p, rowland s e, denis d, et al. mf498 [n-{[4-(5, 9-diethoxy-6-oxo-6, 8-dihydro-7h-pyrrolo [3, 4-g] quinolin-7-yl)-3-methylbenzyl] sulfonyl}-2-(2-methoxyphenyl) acetamide], a selective e prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis[j]. journal of pharmacology and experimental therapeutics, 2008, 325(2): 425-434.

MF498 Preparation Products And Raw materials

Raw materials

Preparation Products

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MF498 Suppliers

China 33 United States 9 Global 42

Musechem

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TargetMol Chemicals Inc.

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Cckinase, Inc.

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BOC Sciences

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Cayman Chemical Company

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Matrix Scientific

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915191-42-3, MF498Related Search:

MF498

N-((4-(5,9-Diethoxy-6-oxo-6H-pyrrolo[3,4-g]quinolin-7(8H)-yl)-3-methylbenzyl)sulfonyl)-2-(2-me

MF498;MF-498;MF 498

CS-2084

Benzeneacetamide, N-[[[4-(5,9-diethoxy-6,8-dihydro-6-oxo-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methyl]sulfonyl]-2-methoxy-

MF498,MF-498

915191-42-3