ChemicalBook > CAS DataBase List > PF-3274167

PF-3274167

Product Name
PF-3274167
CAS No.
900510-03-4
Chemical Name
PF-3274167
Synonyms
IX-01;CS-1465;Cligosiban;PF-3274167;PF-03274167;PF 3274167;PF3274167;PF-3274167(cligosiban);PF3274167, 10 mM in DMSO;PF3274167; PF 3274167; PF-03274167; PF 03274167;5-[3-[3-(2-chloro-4-fluorophenoxy)azetidin-1-yl]-5-(methoxymethyl)-1,2,4-triazol-4-yl]-2-methoxypyridine
CBNumber
CB72628247
Molecular Formula
C19H19ClFN5O3
Formula Weight
419.84
MOL File
900510-03-4.mol
More
Less

PF-3274167 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 18 mg/mL
form 
A crystalline solid
color 
Off-white to pink
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
26189
Product name
PF-3274167
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
26189
Product name
PF-3274167
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
26189
Product name
PF-3274167
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26189
Product name
PF-3274167
Packaging
10mg
Price
$199
Updated
2024/03/01
TRC
Product number
P294160
Product name
PF-3274167
Packaging
50mg
Price
$915
Updated
2021/12/16
More
Less

PF-3274167 Chemical Properties,Usage,Production

Description

PF-3274167 is an oxytocin receptor antagonist (Ki = 9.5 nM). It is selective for the oxytocin receptor over the vasopressin receptors V1A and V2 (Kis = 1,120 and 10,000 nM, respectively).

Uses

PF-3274167 functions as s triazole oxytocin antagonists. It also functions as a PET radiotracer of oxytocin receptors.

in vivo

Cligosiban (0.9 mg/kg; 3 to 5 minutes after injection of Apomorphine (HY-12723); i.v.) shows CNS permeability and inhibits Apomorphine-induced ejaculation in an anesthetized rat CNS neuronal discharge model by modulating oxytocin (OT)-mediated responses in the nucleus tractus solitarius (NTS)[1]. Cligosiban (1 mg/kg; i.v. or p.o.) produces 4 metabolites in rat plasma, with demethylation and glucuronidation being the major metabolic pathways, and the pharmacokinetic profile is favorable[2].

Animal Model:Male Sprague Dawley rats (280-350 g), Anesthetized Rat CNS Neuronal Firing Model (Pre injection of Apomorphine (200 mg/kg, intravenous injection) into rats to regulate neuronal firing)[1].
Dosage:0.9 mg/kg
Administration:Intravenous injection (i.v.); 3 to 5 minutes after injection of Apomorphine
Result:Reversed the reduced firing of nucleus tractus solitaries (NTS) neurons induced by Apomorphine and reduced the bulbospongiosum burst pattern and contraction amplitude associated with ejaculation.
Animal Model:Male Sprague-Dawley rats with body weight of 200-220?g[2].
Dosage:1 mg/kg
Administration:Intravenous injection (i.v.) or oral gavage (p.o.)
Result:Was rapidly absorbed into the plasma after oral administration and reached its maximum blood concentration 1.41 hours after administration, and was quickly eliminated from the plasma after absorption.

References

[1] ALAN BROWN. Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 2: Pages 516-520. DOI: 10.1016/j.bmcl.2009.11.097

PF-3274167 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

PF-3274167 Suppliers

China 60 United Kingdom 1 United States 10 Global 71
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Resuperpharmtech Co., Ltd.
Tel
02150565560; 17321237488
Email
kevin@resuperpharmtech.com
Country
China
ProdList
356
Advantage
58

900510-03-4, PF-3274167Related Search:


  • PF-3274167
  • PF-03274167
  • 5-[3-[3-(2-Chloro-4-fluorophenoxy)-1-azetidinyl]-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl]-2-methoxypyridine
  • 5-[3-[3-(2-chloro-4-fluorophenoxy)azetidin-1-yl]-5-(methoxymethyl)-1,2,4-triazol-4-yl]-2-methoxypyridine
  • Cligosiban
  • PF 3274167;PF3274167
  • PF-3274167(cligosiban)
  • 5-(3-(3-(2-Chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine
  • CS-1465
  • PF3274167; PF 3274167; PF-03274167; PF 03274167
  • Pyridine, 5-[3-[3-(2-chloro-4-fluorophenoxy)-1-azetidinyl]-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl]-2-methoxy-
  • PF3274167, 10 mM in DMSO
  • IX-01
  • 900510-03-4