S-110
- Product Name
- S-110
- CAS No.
- 929904-85-8
- Chemical Name
- S-110
- Synonyms
- S-110;SGI-100;S-110 sodium;Guadecitabine (SGI-110);SGI-110 SODIUM;S-110 SODIUM;XLHBNJPXFOZFNJ-UHFFFAOYSA-M;2'-Deoxy-5-azacytidylyl-(3'→5')-2'-deoxy-guanosine SodiuM Salt;[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] phosphate
- CBNumber
- CB72628373
- Molecular Formula
- C18H25N9NaO10P
- Formula Weight
- 581.41
- MOL File
- 929904-85-8.mol
S-110 Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to off-white
- Water Solubility
- DMSO: 50 mg/mL (86.30 mM); Water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D232200
- Product name
- 2''-Deoxy-5-azacytidylyl-(3''→5'')-2''-deoxy-guanosineSodiumSalt
- Packaging
- 10mg
- Price
- $24750
- Updated
- 2021/12/16
- Product number
- CS-0003821
- Product name
- Guadecitabinesodium
- Purity
- 98.05%
- Packaging
- 5mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0003821
- Product name
- Guadecitabinesodium
- Purity
- 98.05%
- Packaging
- 10mg
- Price
- $1200
- Updated
- 2021/12/16
S-110 Chemical Properties,Usage,Production
Uses
2''-Deoxy-5-azacytidylyl-(3''→5'')-2''-deoxy-guanosine is an DNA methylation inhibitor in vivo and was shown to effectively tolerated in tumor-free mouse and was found to be similarly effective in reducing tumor growth.
Uses
2'-Deoxy-5-azacytidylyl-(3'→5')-2'-deoxy-guanosine is an DNA methylation inhibitor in vivo and was shown to effectively tolerated in tumor-free mouse and was found to be similarly effective in reducing tumor growth.
in vivo
Guadecitabine sodium (SGI-110 sodium) at 10mg/kg is an effective dose at reducing DNA methylation and retarding tumor growth, and caused roughly the same level of toxicity as 5-Aza-CdR. Guadecitabine sodium is effective in vivo at reactivating the expression of the p16 gene, which is heavily methylated in the parent EJ6 cells. Guadecitabine sodium is effective in reducing the level of DNA methylation in vivo at the p16 promoter region. Guadecitabine sodium is better tolerated than 5-Aza-CdR in vivo, suggesting that it can be an attractive alternative for potential clinical use[2].
IC 50
DNMT1
S-110 Preparation Products And Raw materials
Raw materials
Preparation Products
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