ChemicalBook > CAS DataBase List > VidofludiMus

VidofludiMus

Product Name
VidofludiMus
CAS No.
717824-30-1
Chemical Name
VidofludiMus
Synonyms
4SC-101;CS-1196;SC12267);VidofludiMus;VidofludiMus(4SC-101;VIDOFLUDIMUS(4SC-101; SC12267);4SC-101; SC12267;4SC101;4SC 101;2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid;2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid;2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
CBNumber
CB72628520
Molecular Formula
C20H18FNO4
Formula Weight
355.36
MOL File
717824-30-1.mol
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VidofludiMus Property

Boiling point:
567.5±50.0 °C(Predicted)
Density 
1.354±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥103 mg/mL in DMSO
form 
solid
pka
4?+-.0.20(Predicted)
color 
Light yellow to gray
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18377
Product name
Vidofludimus
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
18377
Product name
Vidofludimus
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
18377
Product name
Vidofludimus
Purity
≥98%
Packaging
10mg
Price
$213
Updated
2024/03/01
Cayman Chemical
Product number
18377
Product name
Vidofludimus
Purity
≥98%
Packaging
25mg
Price
$485
Updated
2024/03/01
TRC
Product number
V305033
Product name
Vidofludimus
Packaging
25mg
Price
$330
Updated
2021/12/16
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VidofludiMus Chemical Properties,Usage,Production

Uses

Vidofludimus is an immunosuppressive drug that inhibits dihydroorotate dehydrogenase (DHODH) and the expression of proinflammatory cytokines including interleukin-17 (IL17A and IL17F) and interferon-gamma.

Biological Activity

vidofludimus (4sc-101, sc12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (dhodh) with an ic50 value of 134nmol/l for human dhodh [1].vidofludimus (4sc-101, sc12267) has been reported to dose-dependently inhibit dhodh in an in vitro enzyme assay with ic50 values of 0.134μmol/l, 1.29μmol/l, 10.6μmol/l and 12.9μmol/l in human dhodh, rat dhodh, mouse dhodh and human pbmc, respectively [1]. in addition, vidofludimus has shown the inhibition of proliferation in phytohemagglutinin-induced lymphocytes with an ic50 value of ~13μmol/l. moreover, vidofludimus has been revealed to concentration-dependently inhibit phytohemagglutinin-stimulated interukin-17 secretion from human peripgeral blppd mononuclear cell lines (pbmcs) with an ic50 value of 6 μmol/l [2].

References

[1] kulkarni op1, sayyed sg, kantner c, ryu m, schnurr m, sárdy m, leban j, jankowsky r, ammendola a, doblhofer r, anders hj. 4sc-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in mrl-(fas) lpr mice. am j pathol. 2010 jun;176(6):2840-7.
[2] fitzpatrick lr1, deml l, hofmann c, small js, groeppel m, hamm s, lemstra s, leban j, ammendola a. 4sc-101, a novel immunosuppressive drug, inhibits il-17 and attenuates colitis in two murine models of inflammatory bowel disease. inflamm bowel dis. 2010 oct;16(10):1763-77.

VidofludiMus Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from VidofludiMus manufacturers

airuikechemical co., ltd.
Product
Vidofludimus 717824-30-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-07
Career Henan Chemical Co
Product
VidofludiMus 717824-30-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-12

717824-30-1, VidofludiMusRelated Search:


  • VidofludiMus
  • SC12267)
  • VidofludiMus(4SC-101
  • VIDOFLUDIMUS(4SC-101; SC12267)
  • 2-[[(3-Fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid
  • 2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid
  • 2-[(3-fluoro-3'-methoxybiphenyl-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid Vidofludimus(4SC-101
  • 4SC-101
  • CS-1196
  • 4SC-101; SC12267;4SC101;4SC 101
  • 1-Cyclopentene-1-carboxylic acid, 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-
  • 2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
  • DHODH,fatty liver,Inhibitor,Vidofludimus,Dihydroorotate Dehydrogenase,dihydroorotate dehydrogenase (DHODH),oral,Interleukin Related,SC-12267,FXR,NR1H4,non-alcoholic fatty liver disease (NAFLD),inflammatory bowel disease (IBD),immunomodulatory,farnesoid X receptor (FXR),inhibit,SC 12267
  • 2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
  • 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-ene-1-carboxylic acid
  • 717824-30-1
  • 7178240-30-1
  • API
  • Inhibitors