2-(3-Fluoro-2-nitrophenyl)acetic acid
- Product Name
- 2-(3-Fluoro-2-nitrophenyl)acetic acid
- CAS No.
- 872141-25-8
- Chemical Name
- 2-(3-Fluoro-2-nitrophenyl)acetic acid
- Synonyms
- 2-(3-Fluoro-2-nitrophenyl);3-Fluoro-2-nitrobenzeneacetic acid;Benzeneacetic acid, 3-fluoro-2-nitro-;2-(3-Fluoro-2-nitrophenyl)acetic acid
- CBNumber
- CB72631599
- Molecular Formula
- C8H6FNO4
- Formula Weight
- 199.14
- MOL File
- 872141-25-8.mol
2-(3-Fluoro-2-nitrophenyl)acetic acid Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- F594993
- Product name
- (3-Fluoro-2-nitrophenyl)aceticacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F594993
- Product name
- (3-Fluoro-2-nitrophenyl)aceticacid
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 119761
- Product name
- 2-(3-Fluoro-2-nitrophenyl)acetic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- HCH0362586
- Product name
- 2-(3-FLUORO-2-NITROPHENYL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.39
- Updated
- 2021/12/16
- Product number
- 119761
- Product name
- 2-(3-Fluoro-2-nitrophenyl)acetic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $540
- Updated
- 2021/12/16
2-(3-Fluoro-2-nitrophenyl)acetic acid Chemical Properties,Usage,Production
Uses
(3-Fluoro-2-nitrophenyl)acetic acid
Synthesis
872141-24-7
872141-25-8
General procedure for the synthesis of 2-(3-fluoro-2-nitrophenyl)acetic acid from dimethyl 2-(3-fluoro-2-nitrophenyl)malonate: dimethyl 2-(3-fluoro-2-nitrophenyl)malonate (2.53 g, 9.33 mmol) was suspended in water (20 mL). Concentrated hydrochloric acid (20 mL, 653 mmol) was slowly added to this suspension. The reaction mixture was heated to reflux and maintained under stirring for 5 hours. After completion of the reaction, the mixture was cooled to room temperature. The mixture was extracted twice with ether and the aqueous phase was discarded. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to dryness. The residue was recrystallized by a 5:1 solvent mixture of hexane and ethyl acetate. The precipitated solid was collected, washed with hexane and subsequently dried under vacuum to afford the target compound 2-(3-fluoro-2-nitrophenyl)acetic acid as a white solid in 90% yield.1H NMR (300 MHz, chloroform-d) δ ppm: 3.85 (s, 2H), 7.08-7.19 (m, 1H), 7.20-7.28 (m, 1H), 7.38 -7.55 (m, 1H).
References
[1] Patent: US2007/259851, 2007, A1. Location in patent: Page/Page column 114-115
[2] Patent: US2011/59954, 2011, A1. Location in patent: Page/Page column 94
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1861 - 1873
[4] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 9
2-(3-Fluoro-2-nitrophenyl)acetic acid Preparation Products And Raw materials
Raw materials
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