Methyl 1-Methyl-1H-indole-4-carboxylate
- Product Name
- Methyl 1-Methyl-1H-indole-4-carboxylate
- CAS No.
- 1444-12-8
- Chemical Name
- Methyl 1-Methyl-1H-indole-4-carboxylate
- Synonyms
- Methyl 1-Methyl-4-indolecarboxylate;Methyl 1-Methylindole-4-carboxylate;4-(Methoxycarbonyl)-1-methyl-1H-indole;Methyl 1-Methyl-1H-indole-4-carboxylate;1-methyl-1H-Indole-4-carboxylic acid methyl ester;1H-Indole-4-carboxylic acid, 1-methyl-, methyl ester
- CBNumber
- CB72631610
- Molecular Formula
- C11H11NO2
- Formula Weight
- 189.21
- MOL File
- 1444-12-8.mol
Methyl 1-Methyl-1H-indole-4-carboxylate Property
- Melting point:
- 53 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
- Boiling point:
- 320.2±15.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Crystal
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M338483
- Product name
- Methyl1-Methyl-1H-indole-4-carboxylate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- V3326
- Product name
- Methyl1-methylindole-4-carboxylate
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- 4H23-1-7V
- Product name
- Methyl 1-methyl-1H-indole-4-carboxylate
- Packaging
- 1g
- Price
- $332
- Updated
- 2021/12/16
- Product number
- 088400
- Product name
- Methyl 1-methyl-1H-indole-4-carboxylate
- Packaging
- 1g
- Price
- $448
- Updated
- 2021/12/16
- Product number
- CHM0384686
- Product name
- METHYL-1-METHYL-1H-INDOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.06
- Updated
- 2021/12/16
Methyl 1-Methyl-1H-indole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
39830-66-5
74-88-4
1444-12-8
To a 40 mL reaction vial was added a solution of methyl 1H-indole-4-carboxylate (400 mg, 2.28 mmol, 1.00 equiv) in N,N-dimethylformamide (10 mL). Sodium hydride (275 mg, 6.88 mmol, 3.00 equiv, 60% dispersed in mineral oil) was added in batches at 0 °C. After keeping stirring at 0 °C for 0.5 h, iodomethane (1.298 g, 9.14 mmol, 4.00 eq.) was slowly added dropwise at the same temperature. The reaction mixture was warmed to 25 °C and stirred for 15 hours. After completion of the reaction, the mixture was poured into ice water (50 mL) and extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Methyl 1-methyl-4-indolecarboxylate (429 mg, 99%) was obtained as a red oil after concentration under reduced pressure. Mass spectrum (electrospray ionization, m/z): [M+H]+ 190.
References
[1] Patent: WO2017/205296, 2017, A1. Location in patent: Paragraph 78
[2] Patent: US2009/298809, 2009, A1. Location in patent: Page/Page column 17
[3] Heterocycles, 2006, vol. 67, # 2, p. 643 - 653
Methyl 1-Methyl-1H-indole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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