1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione

Product Name: 1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione
CAS No.: 37468-32-9
Chemical Name: 1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione
Synonyms: ALLO-1;ALLO1,ALLO 1;1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione;3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione;2,4-Imidazolidinedione, 3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-
CBNumber: CB72638846
Molecular Formula: C17H15ClN2O2
Formula Weight: 314.77
MOL File: 37468-32-9.mol

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1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Property

Boiling point:: 452.0±55.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
pka: -1.30±0.40(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0381
Product name: ALLO-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $503
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML0381
Product name: ALLO-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2022/05/15

Cayman Chemical

Product number: 17776
Product name: ALLO-1
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17776
Product name: ALLO-1
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 17776
Product name: ALLO-1
Purity: ≥98%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

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1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Chemical Properties,Usage,Production

Uses

ALLO-1 is a small molecule antagonist that inhibits drug-resistant mutant of Smoothened (Smo), related to cancers.

Biological Activity

allo-1 is a smo antagonist.hedgehog (hh) proteins are important development regulators that bind the cell-surface protein, which allows the activation of a gpcr-like receptor, smoothened (smo). in vertebrates, the smo activation finally results in the activation of the zinc-finger transcription factors of the gli family. in addition, the overactivation of smo may lead to certain cancers.

Biochem/physiol Actions

ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo, including D473H SMO mutant. ALLO-1 binds to a different domain of Smo than other known Smo ligands.

in vitro

previous study found that allo-1 and its close analog allo-2 could inhibit smo agonist hh-ag 1.5-induced luciferase expression in tm3-gli-luc cells. the potency of allo-1 did not change when either low dose or high dose of hh-ag 1.5 was used, in contrast to other known smo antagonists that are strong sag or hh-ag 1.5 competitors. moreover, it was found that in contrast to gdc-0449, both allo-1 and allo-2 inhibited wild-type and the d477g mutant with only around2-fold shift in ic50, indicating that the d477g mutation did not significantly interfere with the binding of allo-1 and allo-2 to smo. in addition, allo-1 as well as allo-2 were able to inhibit both wild-type and d473h mutant human smo with similar potencies [1].

IC 50

50 nm for wile type smo

References

[1] tao, h. ,jin, q.,koo, d.i., et al. small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. chemistry & biology 18, 432-437 (2011).

1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Suppliers

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37468-32-9, 1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dioneRelated Search:

1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione

ALLO-1

3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione

2,4-Imidazolidinedione, 3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-

ALLO1,ALLO 1

37468-32-9

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