1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione
- Product Name
- 1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione
- CAS No.
- 37468-32-9
- Chemical Name
- 1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione
- Synonyms
- ALLO-1;ALLO1,ALLO 1;1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione;3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione;2,4-Imidazolidinedione, 3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-
- CBNumber
- CB72638846
- Molecular Formula
- C17H15ClN2O2
- Formula Weight
- 314.77
- MOL File
- 37468-32-9.mol
1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Property
- Boiling point:
- 452.0±55.0 °C(Predicted)
- Density
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- pka
- -1.30±0.40(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0381
- Product name
- ALLO-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $503
- Updated
- 2023/06/20
- Product number
- SML0381
- Product name
- ALLO-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $113
- Updated
- 2022/05/15
- Product number
- 17776
- Product name
- ALLO-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 17776
- Product name
- ALLO-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 17776
- Product name
- ALLO-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Chemical Properties,Usage,Production
Uses
ALLO-1 is a small molecule antagonist that inhibits drug-resistant mutant of Smoothened (Smo), related to cancers.
Biological Activity
allo-1 is a smo antagonist.hedgehog (hh) proteins are important development regulators that bind the cell-surface protein, which allows the activation of a gpcr-like receptor, smoothened (smo). in vertebrates, the smo activation finally results in the activation of the zinc-finger transcription factors of the gli family. in addition, the overactivation of smo may lead to certain cancers.
Biochem/physiol Actions
ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo, including D473H SMO mutant. ALLO-1 binds to a different domain of Smo than other known Smo ligands.
in vitro
previous study found that allo-1 and its close analog allo-2 could inhibit smo agonist hh-ag 1.5-induced luciferase expression in tm3-gli-luc cells. the potency of allo-1 did not change when either low dose or high dose of hh-ag 1.5 was used, in contrast to other known smo antagonists that are strong sag or hh-ag 1.5 competitors. moreover, it was found that in contrast to gdc-0449, both allo-1 and allo-2 inhibited wild-type and the d477g mutant with only around2-fold shift in ic50, indicating that the d477g mutation did not significantly interfere with the binding of allo-1 and allo-2 to smo. in addition, allo-1 as well as allo-2 were able to inhibit both wild-type and d473h mutant human smo with similar potencies [1].
IC 50
50 nm for wile type smo
References
[1] tao, h. ,jin, q.,koo, d.i., et al. small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. chemistry & biology 18, 432-437 (2011).
1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Preparation Products And Raw materials
Raw materials
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