2-Thiophenecarboxylic acid, 4-broMo-, ethyl ester
- Product Name
- 2-Thiophenecarboxylic acid, 4-broMo-, ethyl ester
- CAS No.
- 62224-17-3
- Chemical Name
- 2-Thiophenecarboxylic acid, 4-broMo-, ethyl ester
- Synonyms
- Ethyl 4-bromothiophene-2-carboxylate;4-Bromo-2-thiophenecarboxylic acid ethyl ester;4-Bromo-thiophene-2-carboxylic acid ethyl ester;2-Thiophenecarboxylic acid, 4-broMo-, ethyl ester
- CBNumber
- CB72639207
- Molecular Formula
- C7H7BrO2S
- Formula Weight
- 235.1
- MOL File
- 62224-17-3.mol
2-Thiophenecarboxylic acid, 4-broMo-, ethyl ester Property
- Boiling point:
- 107-108 °C(Press: 3 Torr)
- Density
- 1.572±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C7H7BrO2S/c1-2-10-7(9)6-3-5(8)4-11-6/h3-4H,2H2,1H3
- InChIKey
- SLNFTOHTVYSKLD-UHFFFAOYSA-N
- SMILES
- C1(C(OCC)=O)SC=C(Br)C=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9351AB
- Product name
- Ethyl4-bromothiophene-2-carboxylate
- Packaging
- 10g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- HCH0368881
- Product name
- ETHYL-4-BROMOTHIOPHENE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.06
- Updated
- 2021/12/16
- Product number
- 9351AB
- Product name
- Ethyl4-bromothiophene-2-carboxylate
- Packaging
- 25g
- Price
- $677
- Updated
- 2021/12/16
- Product number
- AS018680
- Product name
- Ethyl4-bromothiophene-2-carboxylate
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $17
- Updated
- 2021/12/16
- Product number
- A143192
- Product name
- Ethyl4-bromothiophene-2-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $17
- Updated
- 2021/12/16
2-Thiophenecarboxylic acid, 4-broMo-, ethyl ester Chemical Properties,Usage,Production
Synthesis
16694-18-1
64-17-5
62224-17-3
Example 7A Synthesis of ethyl 4-bromothiophene-2-carboxylate: 663 mg (3.20 mmol) of 4-bromothiophene-2-carboxylic acid (the compound of Example 6A) was dissolved in 25 mL of ethanol and 0.1 mL of concentrated sulfuric acid was added as a catalyst. The reaction mixture was heated to reflux and kept reacting overnight. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the addition of saturated aqueous sodium bicarbonate solution to neutralize the reaction system. The mixture was diluted with water and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate, filtered to remove the desiccant and the filtrate was concentrated under reduced pressure. After the above steps, 700 mg of the target product ethyl 4-bromo-2-thiophenecarboxylate was obtained in 89% yield of the theoretical value. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ= 8.07 (d, 1H), 7.78 (d, 1H), 4.30 (q, 2H), 1.30 (t, 3H). GC-MS analysis (Method 11) showed: retention time Rt = 4.69 min; mass spectrum (EIpos): m/z = 234 [M]+.
References
[1] Patent: US2012/22123, 2012, A1. Location in patent: Page/Page column 13
2-Thiophenecarboxylic acid, 4-broMo-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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