5-Fluoro-2-hydroxybenzonitrile

Product Name: 5-Fluoro-2-hydroxybenzonitrile
CAS No.: 91407-41-9
Chemical Name: 5-Fluoro-2-hydroxybenzonitrile
Synonyms: 2-Cyano-4-fluorophenol;5-Fluoro-2-hydroxybenzonitrile;2-hydroxy-5-fluorobenzonitrile;Benzonitrile, 5-fluoro-2-hydroxy-
CBNumber: CB72640924
Molecular Formula: C7H4FNO
Formula Weight: 137.11
MOL File: 91407-41-9.mol

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5-Fluoro-2-hydroxybenzonitrile Property

storage temp.: Inert atmosphere,Room Temperature
form: solid
color: White to yellow

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F595503
Product name: 5-Fluoro-2-hydroxybenzonitrile
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 076820
Product name: 5-Fluoro-2-hydroxybenzonitrile
Packaging: 1g
Price: $195
Updated: 2021/12/16

AK Scientific

Product number: 5308AC
Product name: 5-Fluoro-2-hydroxybenzonitrile
Packaging: 5g
Price: $397
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0105236
Product name: 5-FLUORO-2-HYDROXYBENZONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $505.3
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35830
Product name: 5-Fluoro-2-hydroxybenzonitrile
Purity: 95+%
Packaging: 5G
Price: $660
Updated: 2021/12/16

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5-Fluoro-2-hydroxybenzonitrile Chemical Properties,Usage,Production

Synthesis

91407-40-8

91407-41-9

5-Fluoro-2-hydroxybenzaldehyde oxime (920 mg, 5.93 mmol) was used as a raw material and dissolved in acetic anhydride (15 mL). Subsequently, a solution consisting of KOH (2 g) dissolved in H2O (10 mL) and ethanol (10 mL) was added to the mixture. The reaction mixture was heated at 80 °C for 2 h, after which it was cooled to room temperature. The pH of the reaction solution was adjusted to 7 with 6N HCl and then extracted twice with a solvent mixture of isopropanol/dichloromethane (1:3, v/v). The organic layers were combined and dried with anhydrous sodium sulfate. The resulting residue was purified by silica gel column chromatography using hexane/ethyl acetate (5:1, v/v) as eluent to afford the target product 2-hydroxy-5-fluorobenzonitrile (800 mg, 100% yield). The mass spectrum (DCI/NH3) showed m/z 136 (M + 1)+. 1H NMR (500 MHz, DMSO-d6) δ ppm: 6.99 (dd, J = 9.05, 4.37 Hz, 1H), 7.36 (td, J = 9.05, 3.12 Hz, 1H), 7.53 (dd, J = 8.42, 3.43 Hz, 1H). 11.04 (m, 1H).

References

[1] Patent: WO2005/111003, 2005, A1. Location in patent: Page/Page column 131
[2] Patent: EP2258697, 2010, A1. Location in patent: Page/Page column 40
[3] Patent: CN107778216, 2018, A. Location in patent: Paragraph 0023; 0024
[4] Patent: CN107778215, 2018, A. Location in patent: Paragraph 0023; 0024

5-Fluoro-2-hydroxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoro-2-hydroxybenzonitrile Suppliers

China 48 India 1 United Kingdom 1 United States 7 Global 57

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91407-41-9, 5-Fluoro-2-hydroxybenzonitrileRelated Search:

5-Fluoro-2-hydroxybenzonitrile

Benzonitrile, 5-fluoro-2-hydroxy-

2-hydroxy-5-fluorobenzonitrile

2-Cyano-4-fluorophenol

91407-41-9