5-Fluoro-2-hydroxybenzonitrile
- Product Name
- 5-Fluoro-2-hydroxybenzonitrile
- CAS No.
- 91407-41-9
- Chemical Name
- 5-Fluoro-2-hydroxybenzonitrile
- Synonyms
- 2-Cyano-4-fluorophenol;5-Fluoro-2-hydroxybenzonitrile;2-hydroxy-5-fluorobenzonitrile;Benzonitrile, 5-fluoro-2-hydroxy-
- CBNumber
- CB72640924
- Molecular Formula
- C7H4FNO
- Formula Weight
- 137.11
- MOL File
- 91407-41-9.mol
5-Fluoro-2-hydroxybenzonitrile Property
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- color
- White to yellow
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F595503
- Product name
- 5-Fluoro-2-hydroxybenzonitrile
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 076820
- Product name
- 5-Fluoro-2-hydroxybenzonitrile
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 5308AC
- Product name
- 5-Fluoro-2-hydroxybenzonitrile
- Packaging
- 5g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- HCH0105236
- Product name
- 5-FLUORO-2-HYDROXYBENZONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.3
- Updated
- 2021/12/16
- Product number
- 35830
- Product name
- 5-Fluoro-2-hydroxybenzonitrile
- Purity
- 95+%
- Packaging
- 5G
- Price
- $660
- Updated
- 2021/12/16
5-Fluoro-2-hydroxybenzonitrile Chemical Properties,Usage,Production
Synthesis
91407-40-8
91407-41-9
5-Fluoro-2-hydroxybenzaldehyde oxime (920 mg, 5.93 mmol) was used as a raw material and dissolved in acetic anhydride (15 mL). Subsequently, a solution consisting of KOH (2 g) dissolved in H2O (10 mL) and ethanol (10 mL) was added to the mixture. The reaction mixture was heated at 80 °C for 2 h, after which it was cooled to room temperature. The pH of the reaction solution was adjusted to 7 with 6N HCl and then extracted twice with a solvent mixture of isopropanol/dichloromethane (1:3, v/v). The organic layers were combined and dried with anhydrous sodium sulfate. The resulting residue was purified by silica gel column chromatography using hexane/ethyl acetate (5:1, v/v) as eluent to afford the target product 2-hydroxy-5-fluorobenzonitrile (800 mg, 100% yield). The mass spectrum (DCI/NH3) showed m/z 136 (M + 1)+. 1H NMR (500 MHz, DMSO-d6) δ ppm: 6.99 (dd, J = 9.05, 4.37 Hz, 1H), 7.36 (td, J = 9.05, 3.12 Hz, 1H), 7.53 (dd, J = 8.42, 3.43 Hz, 1H). 11.04 (m, 1H).
References
[1] Patent: WO2005/111003, 2005, A1. Location in patent: Page/Page column 131
[2] Patent: EP2258697, 2010, A1. Location in patent: Page/Page column 40
[3] Patent: CN107778216, 2018, A. Location in patent: Paragraph 0023; 0024
[4] Patent: CN107778215, 2018, A. Location in patent: Paragraph 0023; 0024
5-Fluoro-2-hydroxybenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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