1-BroMo-4-chloro-5-fluoro-2-nitrobenzene
- Product Name
- 1-BroMo-4-chloro-5-fluoro-2-nitrobenzene
- CAS No.
- 960000-93-5
- Chemical Name
- 1-BroMo-4-chloro-5-fluoro-2-nitrobenzene
- Synonyms
- 2-Bromo-5-chloro-4-fluoronitrobenzene;1-BroMo-4-chloro-5-fluoro-2-nitrobenzene;Benzene, 1-bromo-4-chloro-5-fluoro-2-nitro-;1-BroMo-4-chloro-5-fluoro-2-nitrobenzene ISO 9001：2015 REACH
- CBNumber
- CB72641835
- Molecular Formula
- C6H2BrClFNO2
- Formula Weight
- 254.44
- MOL File
- 960000-93-5.mol
1-BroMo-4-chloro-5-fluoro-2-nitrobenzene Property
- Boiling point:
- 247.2±35.0 °C(Predicted)
- Density
- 1.904±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Yellow to brown Solid
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683148
- Product name
- 1-Bromo-4-chloro-5-fluoro-2-nitrobenzene
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B683148
- Product name
- 1-Bromo-4-chloro-5-fluoro-2-nitrobenzene
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FB141069
- Product name
- 1-Bromo-4-chloro-5-fluoro-2-nitrobenzene
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 4654-F-03
- Product name
- 2-Bromo-5-chloro-4-fluoronitrobenzene
- Packaging
- 1g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- FB141069
- Product name
- 1-Bromo-4-chloro-5-fluoro-2-nitrobenzene
- Packaging
- 250mg
- Price
- $72.5
- Updated
- 2021/12/16
1-BroMo-4-chloro-5-fluoro-2-nitrobenzene Chemical Properties,Usage,Production
Synthesis
60811-18-9
960000-93-5
Step A - Synthesis of 1-bromo-4-chloro-5-fluoro-2-nitrobenzene: To a solution of 4-bromo-1-chloro-2-fluorobenzene (8.4 g, 40 mmol) and ammonium nitrate in dichloromethane (DCM, 335 mL) was slowly added trifluoroacetic anhydride (TFA anhydride, 41.3 mL) through the addition funnel over a 15-minute period, keeping the reaction temperature at 0 °C. After addition, the reaction mixture was continued to be stirred at 0 °C for 15 min, and then raised to room temperature and stirred for 2 h. The reaction was then carried out at 0 °C for 2 h. The reaction was then carried out at 0 °C for 2 h. Upon completion of the reaction, the reaction was quenched with 560 mL of saturated sodium bicarbonate (NaHCO3) solution and the organic and aqueous layers were separated. The aqueous layer was extracted with DCM and ethyl acetate (EtOAc), respectively. All organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and added to silica gel. The solvent was removed by concentration under reduced pressure and the residue was purified by fast column chromatography (elution gradient: 0 to 15% EtOAc/hexane) to afford the target product 1-bromo-4-chloro-5-fluoro-2-nitrobenzene 3.7 g in 36% yield.1H NMR (400 MHz, DMSO-d6): δ 8.46 (d, J = 6.9 Hz, 1H), 8.18 (d, J = 8.8 Hz, 1H).
References
[1] Patent: US2008/300247, 2008, A1. Location in patent: Page/Page column 67
[2] Patent: WO2007/143456, 2007, A2. Location in patent: Page/Page column 223
1-BroMo-4-chloro-5-fluoro-2-nitrobenzene Preparation Products And Raw materials
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