1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro-
- Product Name
- 1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro-
- CAS No.
- 37964-14-0
- Chemical Name
- 1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro-
- Synonyms
- 2,3,4,9-Tetrahydro-1H-carbazole-2-carboxylic ...;2,3,4,9-Tetrahydro-1H-carbazole-2-carboxylic acid;1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro-
- CBNumber
- CB72645611
- Molecular Formula
- C13H13NO2
- Formula Weight
- 215.25
- MOL File
- 37964-14-0.mol
1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro- Property
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Z4679
- Product name
- 2,3,4,9-Tetrahydro-1H-carbazole-2-carboxylicacid
- Packaging
- 100mg
- Price
- $266
- Updated
- 2021/12/16
- Product number
- CHM0387633
- Product name
- 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.4
- Updated
- 2021/12/16
- Product number
- A126994
- Product name
- 2,3,4,9-Tetrahydro-1H-carbazole-2-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $625
- Updated
- 2021/12/16
- Product number
- 37964140
- Product name
- 2,3,4,9-Tetrahydro-1H-carbazole-2-carboxylicacid
- Packaging
- 1g
- Price
- $625.24
- Updated
- 2021/12/16
- Product number
- CD11132701
- Product name
- 2,3,4,9-Tetrahydro-1H-carbazole-2-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $632
- Updated
- 2021/12/16
1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro- Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron, 28, p. 667, 1972 DOI: 10.1016/0040-4020(72)84030-4
Synthesis
16205-98-4
100-63-0
37964-14-0
GENERAL STEPS: 3-oxocyclohexanecarboxylic acid (200 mg, 1.407 mmol) was dissolved in acetic acid (3 mL), and a solution of phenylhydrazine (160 mg, 1.480 mmol) in acetic acid (2 mL) was slowly added with stirring at room temperature. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and extracted with brine. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was recrystallized by ethyl acetate/hexane to give a light brown microcrystalline solid 2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid (191 mg, 63% yield) with a melting point of 235-238 °C (literature values: Asselin et al. J. Med. Chem., 1976, 19, 787-792, melting point 239-241 °C; Allen et al. J. Heterocyclic Chem., 1970, 7, 239-241, melting point 233-235°C). IR (KBr, cm-1): 3416, 3048, 2923, 2844, 1689, 1465, 1444, 1415, 1288, 1264, 1226, 935, 740. 1H NMR (DMSO-d6, δ): 12.27 (1H, s), 10.66 (1H, s), 7.33 (1H, d, J = 7.6 Hz), 7.24 (1H, d, J = 7.6 Hz), 6.98 (1H, dt, J = 1.2 Hz, J = 6.8 Hz), 6.91 (1H, dt, J = 1.2 Hz, J = 6.8 Hz), 2.89-2.62 (5H, m), 2.17 (1H, m), 1.87-1.81 (1H, m).
References
[1] Patent: WO2006/82409, 2006, A2. Location in patent: Page/Page column 15
1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro- Preparation Products And Raw materials
Raw materials
Preparation Products
1h-carbazole-2-carboxylic acid, 2,3,4,9-tetrahydro- Suppliers
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