ChemicalBook > CAS DataBase List > 6-broMo-4-Methoxypyrazolo[1,5-a]pyridine

6-broMo-4-Methoxypyrazolo[1,5-a]pyridine

Product Name
6-broMo-4-Methoxypyrazolo[1,5-a]pyridine
CAS No.
1207557-36-5
Chemical Name
6-broMo-4-Methoxypyrazolo[1,5-a]pyridine
Synonyms
6-phenyl-1H-pyrimidin-4-one;6-broMo-4-Methoxypyrazolo[1,5-a]pyridine;Pyrazolo[1,5-a]pyridine, 6-bromo-4-methoxy-
CBNumber
CB72655386
Molecular Formula
C8H7BrN2O
Formula Weight
227.06
MOL File
1207557-36-5.mol
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6-broMo-4-Methoxypyrazolo[1,5-a]pyridine Property

Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
1.29±0.30(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C8H7BrN2O/c1-12-8-4-6(9)5-11-7(8)2-3-10-11/h2-5H,1H3
InChIKey
ARTWAYAZELEWIT-UHFFFAOYSA-N
SMILES
C12=CC=NN1C=C(Br)C=C2OC
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC
Product number
B679495
Product name
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine
Packaging
50mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
3626AA
Product name
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine
Packaging
1g
Price
$388
Updated
2021/12/16
Apolloscientific
Product number
OR49065
Product name
6-Bromo-4-methoxy-pyrazolo[1,5-a]pyridine
Packaging
250mg
Price
$419
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0367783
Product name
6-BROMO-4-METHOXYPYRAZOLO[1,5-A]PYRIDINE
Purity
95.00%
Packaging
5MG
Price
$498.59
Updated
2021/12/16
Apolloscientific
Product number
OR49065
Product name
6-Bromo-4-methoxy-pyrazolo[1,5-a]pyridine
Packaging
1g
Price
$912
Updated
2021/12/16
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6-broMo-4-Methoxypyrazolo[1,5-a]pyridine Chemical Properties,Usage,Production

Uses

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine can be used as RET kinase inhibitors to treat RET-related diseases.

Synthesis

1207557-35-4

1207557-36-5

Step B: Decarboxylation Ethyl 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate (15, 5.2 g, 18.24 mmol) was dissolved in hydrobromic acid (100 mL, 884 mmol), and the reaction was heated to 100 °C for 1 hour. After completion of the reaction, the mixture was cooled to 0 °C and neutralized with 1 M sodium hydroxide solution (182 mL, 912 mmol). The reaction mixture was diluted with ethyl acetate and washed sequentially with 1 N aqueous sodium hydroxide solution and saturated brine, and the organic phase was dried with anhydrous sodium sulfate. After filtration and concentration, the residue was purified by column chromatography (eluent: 0-35% hexane solution of ethyl acetate, linear gradient) to afford 6-bromo-4-methoxypyrazolo[1,5-a]pyridine (16, 2.475 g, 10.90 mmol, 60% yield). Mass spectrum (APCI): m/z 228.1 [M+H]+. Scheme 2: Molecules of type 21 were prepared according to Scheme 2. O- homotrimethylbenzenesulfonyl hydroxylamine (1) was used to prepare N-imino-pyridinium-based methanesulfonate 14, which was used to obtain pyrazolopyridine 15 via [3+2] cycloaddition reaction with ethyl propargylate. decarboxylation in pure hydrobromic acid gave 16. 6-position functionalization of the pyrazolopyridine nucleus was accomplished via a Suzuki coupling reaction to introduce aryl or heteroaryl functional groups (17), see WO 2004052286 A2 and WO 2007085873 A1 for specific borate ester examples. halogenation by reaction with N-iodosuccinimide gave the iodide 18, which was followed by a second Suzuki coupling with the thioborate ester to give the coupling product 19. hydrolysis of the ester yielded the acid 20, which was finally coupled with an amine to give the target compound 21 .

References

[1] Patent: WO2010/17046, 2010, A1. Location in patent: Page/Page column 43-44; 111-112

6-broMo-4-Methoxypyrazolo[1,5-a]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-broMo-4-Methoxypyrazolo[1,5-a]pyridine Suppliers

China 78 India 2 United States 5 Global 85
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 6-broMo-4-Methoxypyrazolo[1,5-a]pyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
6-broMo-4-Methoxypyrazolo[1,5-a]pyridine 1207557-36-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-10
Henan Aochuang Chemical Co.,Ltd.
Product
6-broMo-4-Methoxypyrazolo[1,5-a]pyridine 1207557-36-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Henan Fengda Chemical Co., Ltd
Product
6-broMo-4-Methoxypyrazolo[1,5-a]pyridine 1207557-36-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-10

1207557-36-5, 6-broMo-4-Methoxypyrazolo[1,5-a]pyridineRelated Search:

6-BroMo-4-Methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde 1,3-Benzodioxole, 6-bromo-4-methoxy-

  • 6-broMo-4-Methoxypyrazolo[1,5-a]pyridine
  • 6-phenyl-1H-pyrimidin-4-one
  • Pyrazolo[1,5-a]pyridine, 6-bromo-4-methoxy-
  • 1207557-36-5