(3-broMo-2-Methylphenyl)Methanol
Application- Product Name
- (3-broMo-2-Methylphenyl)Methanol
- CAS No.
- 83647-43-2
- Chemical Name
- (3-broMo-2-Methylphenyl)Methanol
- Synonyms
- 3-BroMo-2-Methylbenzyl alcohol;2-methyl-3-bromobenzyl alcohol;(3-broMo-2-Methylphenyl)Methano;(3-broMo-2-Methylphenyl)Methanol;3-Bromo-2-methylbenzylalcohol97%;3-Bromo-2-methyl-benzenemethanol;3-Bromo-2-methylbenzyl alcohol 97%;Benzenemethanol, 3-bromo-2-methyl-;(3-broMo-2-Methylphenyl)Methanol ISO 9001：2015 REACH;(3-Bromo-2-methylphenyl)methanol, (3-Bromo-o-tolyl)methanol
- CBNumber
- CB72658549
- Molecular Formula
- C8H9BrO
- Formula Weight
- 201.06
- MOL File
- 83647-43-2.mol
(3-broMo-2-Methylphenyl)Methanol Property
- Melting point:
- 103-104 °C(Solv: benzene (71-43-2))
- Boiling point:
- 286.4±25.0 °C(Predicted)
- Density
- 1.481±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline needles
- pka
- 14.29±0.10(Predicted)
- color
- Faint beige to faint brown
Safety
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B405320
- Product name
- (3-Bromo-2-methylphenyl)methanol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B405320
- Product name
- (3-Bromo-2-methylphenyl)methanol
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W000403
- Product name
- 3-Bromo-2-methylbenzylalcohol
- Purity
- 99.52%
- Packaging
- 250mg
- Price
- $8
- Updated
- 2021/12/16
- Product number
- 2701-9-06
- Product name
- 3-Bromo-2-methylbenzyl alcohol
- Purity
- 97%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W000403
- Product name
- 3-Bromo-2-methylbenzylalcohol
- Purity
- 99.52%
- Packaging
- 5g
- Price
- $76
- Updated
- 2021/12/16
(3-broMo-2-Methylphenyl)Methanol Chemical Properties,Usage,Production
Application
3-Bromo-2-methylbenzyl alcohol is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis.
Description
3-Bromo-2-methylbenzyl alcohol is a pharmaceutical intermediate, which is obtained by esterification and reduction of 3-bromo-2-methylbenzoic acid. Literature reports that 3-bromo-2-methylbenzyl alcohol can be used to prepare fused ring compounds as PD-1/PD-L1 inhibitors, which have the advantages of high activity, high bioavailability, drug stability, and oral administration.
Synthesis
76006-33-2
83647-43-2
(1) Synthesis of (3-bromo-2-methylphenyl)methanol [99-1] (hereinafter referred to as compound [99-1]) 3-Bromo-2-methylbenzoic acid (1.08 g, 5.0 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL) and cooled in an ice bath to 0°C. To this solution, sodium borohydride (1.15 g, 30.4 mmol) was added batchwise under stirring. Subsequently, a tetrahydrofuran (16 mL) solution of iodine (3.81 g, 15.0 mmol) was added to the reaction mixture in two slow drops. After addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the reaction was quenched by the slow addition of 4N hydrochloric acid (20 mL) under the cooling of the ice bath. The reaction mixture was extracted with ethyl acetate (3 × 20 mL) and the organic phases were combined. The organic phase was washed sequentially with 2N aqueous sodium hydroxide (20 mL) and saturated saline (20 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 4:1) to afford the title compound (3-bromo-2-methylphenyl)methanol (934 mg, 86% yield) as a white solid. 1H-NMR (400 MHz, CDCl3) δ: 7.52-7.50 (1H, m), 7.32 (1H, d, J = 7.6 Hz), 7.06 (1H, t, J = 7.8 Hz), 4.73 (2H, d, J = 5.9 Hz), 2.43 (3H, s), 1.58 (1H, t, J = 5.9 Hz).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5857 - 5867
[2] Patent: WO2017/118762, 2017, A1. Location in patent: Page/Page column 39
[3] Patent: US2006/173183, 2006, A1. Location in patent: Page/Page column 119-120
[4] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 144-145
[5] Patent: US2008/21024, 2008, A1. Location in patent: Page/Page column 63
(3-broMo-2-Methylphenyl)Methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (3-broMo-2-Methylphenyl)Methanol manufacturers
- Product
- 3-Bromo-2-methylbenzyl Alcohol 83647-43-2
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-30
- Product
- (3-broMo-2-Methylphenyl)Methanol 83647-43-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-08
- Product
- (3-broMo-2-Methylphenyl)Methanol 83647-43-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-08-07