3-benzyl-[1,2]oxathiolane 2,2-dioxide
- Product Name
- 3-benzyl-[1,2]oxathiolane 2,2-dioxide
- CAS No.
- 75732-43-3
- Chemical Name
- 3-benzyl-[1,2]oxathiolane 2,2-dioxide
- Synonyms
- 3-Benzyloxathiolane 2,2-dioxide;3-benzyl-[1,2]oxathiolane 2,2-dioxide;1,2-Oxathiolane, 3-(phenylmethyl)-, 2,2-dioxide
- CBNumber
- CB72658554
- Molecular Formula
- C10H12O3S
- Formula Weight
- 212.27
- MOL File
- 75732-43-3.mol
3-benzyl-[1,2]oxathiolane 2,2-dioxide Property
- storage temp.
- 2-8°C
- Appearance
- Yellow to brown Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A157694
- Product name
- 3-Benzyl-1,2-oxathiolane2,2-dioxide
- Purity
- 95%
- Packaging
- 250mg
- Price
- $23
- Updated
- 2021/12/16
- Product number
- A157694
- Product name
- 3-Benzyl-1,2-oxathiolane2,2-dioxide
- Purity
- 95%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CM254925
- Product name
- 3-Benzyl-1,2-oxathiolane2,2-dioxide
- Purity
- 95%
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- A157694
- Product name
- 3-Benzyl-1,2-oxathiolane2,2-dioxide
- Purity
- 95%
- Packaging
- 5g
- Price
- $272
- Updated
- 2021/12/16
- Product number
- CD12036059
- Product name
- 3-Benzyl-1,2-oxathiolane2,2-dioxide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $381
- Updated
- 2021/12/16
3-benzyl-[1,2]oxathiolane 2,2-dioxide Chemical Properties,Usage,Production
Synthesis
100-39-0
75732-43-3
The general procedure for the synthesis of 3-benzyl-1,2-oxathiolane 2,2-dioxide from benzyl bromide was as follows: a 1,3-propanesulfonolactone solution of 4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-1-phenyl-2-butanesulfonic acid up to -78°C (5.0 g, 41 mmol) was prepared in anhydrous THF (150 mL) by the addition of butyl lithium ( 2.5 M hexane solution, 18 mL, 41 mmol). The reaction mixture was stirred at -78 °C for 0.5 h, followed by the slow addition of benzyl bromide (4.9 mL, 41 mmol) via syringe pump over 0.5 h. The reaction mixture was stirred for 0.5 h at -78 °C. Stirring of the reaction mixture was continued at -78 °C for 2 hours. Afterwards, the reaction mixture was warmed to 0 °C and water (100 mL) was slowly added to quench the reaction. The organic layer was separated and the aqueous phase was extracted with EtOAc (2 x 25 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. Purification by fast chromatography (unfolding agent ratio 80% Hex/EtOAc, Rf = 0.14) afforded the target product 1-benzyl-1,3-propanesulfonic acid lactone (5.23 g, 60% yield).
References
[1] Patent: US2006/183800, 2006, A1. Location in patent: Page/Page column 69
3-benzyl-[1,2]oxathiolane 2,2-dioxide Preparation Products And Raw materials
Raw materials
Preparation Products
3-benzyl-[1,2]oxathiolane 2,2-dioxide Suppliers
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- United States
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