6-BroMo-3,4-dihydroquinazolin-2(1H)-one

Product Name: 6-BroMo-3,4-dihydroquinazolin-2(1H)-one
CAS No.: 1246765-38-7
Chemical Name: 6-BroMo-3,4-dihydroquinazolin-2(1H)-one
Synonyms: 6-Bromo-3,4-dihydroquinazolin-2(1H);6-Bromo-3,4-dihydro-1H-quizolin-2-one;6-Bromo-3,4-dihydro-1H-quinazolin-2-one;6-BroMo-3,4-dihydroquinazolin-2(1H)-one;2(1H)-Quinazolinone, 6-bromo-3,4-dihydro-
CBNumber: CB72661154
Molecular Formula: C8H7BrN2O
Formula Weight: 227.06
MOL File: 1246765-38-7.mol

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6-BroMo-3,4-dihydroquinazolin-2(1H)-one Property

Boiling point:: 309.5±42.0 °C(Predicted)
Density: 1.610±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.13±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B997873
Product name: 6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 3456AJ
Product name: 6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging: 250mg
Price: $177
Updated: 2021/12/16

AK Scientific

Product number: 3456AJ
Product name: 6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging: 1g
Price: $373
Updated: 2021/12/16

AK Scientific

Product number: 3456AJ
Product name: 6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging: 5g
Price: $1021
Updated: 2021/12/16

AK Scientific

Product number: 3456AJ
Product name: 6-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging: 10g
Price: $1508
Updated: 2021/12/16

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6-BroMo-3,4-dihydroquinazolin-2(1H)-one Chemical Properties,Usage,Production

Synthesis

771583-12-1

32315-10-9

1246765-38-7

Step 2: Synthesis of 6-bromo-3,4-dihydroquinazolin-2(1H)-one; Triethylamine (0.454 g, 4.5 mmol) was added slowly and dropwise to a solution of tetrahydrofuran (20 mL) containing triphosgene (0.445 g, 1.5 mmol) at 0 °C and under nitrogen protection. After stirring the reaction mixture for 30 minutes, a solution of 2-aminomethyl-4-bromoaniline (0.201 g, 1 mmol) in tetrahydrofuran (10 mL) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was diluted with water (15 mL) and the pH was adjusted to 8-9 with 1 M aqueous sodium hydroxide solution.Subsequently, it was extracted three times with ethyl acetate (30 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by recrystallization from a solvent mixture of dichloromethane and ethyl ether to afford 6-bromo-3,4-dihydroquinazolin-2-one (0.13 g, 57.5% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δppm: 9.12 (s, 1H), 7.29 (s, 1H), 7.27 (d, J=8.4 Hz. 1H), 6.87 (s, 1H), 6.70 (d, J=8.4Hz, 1H), 4.28 (s, 2H).

References

[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 62
[2] Asian Journal of Chemistry, 2014, vol. 26, # 7, p. 2031 - 2036
[3] Patent: US2015/232448, 2015, A1. Location in patent: Paragraph 0048

6-BroMo-3,4-dihydroquinazolin-2(1H)-one Preparation Products And Raw materials

Raw materials

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View Lastest Price from 6-BroMo-3,4-dihydroquinazolin-2(1H)-one manufacturers

Career Henan Chemical Co

Product: 6-BroMo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

Career Henan Chemical Co

Product: 6-BroMo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

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