8-Nitroquinolin-2(1H)-one
- Product Name
- 8-Nitroquinolin-2(1H)-one
- CAS No.
- 7461-12-3
- Chemical Name
- 8-Nitroquinolin-2(1H)-one
- Synonyms
- 8-nitroquinolin-2-ol;8-Nitroquinolin-2(1H)-one;2(1H)-Quinolinone, 8-nitro-;8-nitro-1,2-dihydroquinolin-2-one
- CBNumber
- CB72661765
- Molecular Formula
- C9H6N2O3
- Formula Weight
- 190.16
- MOL File
- 7461-12-3.mol
8-Nitroquinolin-2(1H)-one Property
- storage temp.
- Sealed in dry,Room Temperature
Safety
- HS Code
- 2933499090
N-Bromosuccinimide Price
- Product number
- N520153
- Product name
- 8-Nitroquinolin-2(1H)-one
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- OR925748
- Product name
- 8-Nitroquinolin-2(1H)-one
- Purity
- 95%
- Packaging
- 5g
- Price
- $380
- Updated
- 2021/12/16
- Product number
- OR925748
- Product name
- 8-Nitroquinolin-2(1H)-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- Z5094
- Product name
- 8-Nitroquinolin-2(1H)-one
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CHM0391748
- Product name
- 8-NITROQUINOLIN-2(1H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.1
- Updated
- 2021/12/16
8-Nitroquinolin-2(1H)-one Chemical Properties,Usage,Production
Synthesis
4225-86-9
7461-12-3
General procedure for the synthesis of 8-nitroquinolin-2(1H)-ones from 2-chloro-8-nitroquinoline: 2-chloro-8-nitroquinoline (1 equiv.) was dissolved in acetonitrile (25 mL) and 70% perchloric acid solution (25 mL) was added. The reaction mixture was stirred at 100°C overnight. Upon completion of the reaction, the mixture was poured into ice water and neutralized to neutral with KOH solution. The organic layer was extracted twice with dichloromethane and combined. The organic layer was washed with water and then dried with anhydrous MgSO4. After drying, the solvent was removed by vacuum evaporation to give the crude product. Purification by silica gel column chromatography using a suitable eluent and recrystallization if necessary gave the target compound 8-nitroquinolin-2(1H)-one. Isolation of 4-methyl-8-nitroquinolin-2(1H)-one 7 (C10H8N2O3) and recrystallization resulted in a yellow solid in acetonitrile in 92% yield (11 mmol, 2.2 g).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 135 - 152
[2] ChemMedChem, 2018,
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 2000, vol. 4, p. 555 - 562
[4] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 112
[5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 76
8-Nitroquinolin-2(1H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
8-Nitroquinolin-2(1H)-one Suppliers
- Tel
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- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
- Tel
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- info@chemsworth.com
- Country
- India
- ProdList
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View Lastest Price from 8-Nitroquinolin-2(1H)-one manufacturers
- Product
- 8-Nitroquinolin-2(1H)-one 7461-12-3
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-07
- Product
- 8-Nitroquinolin-2(1H)-one 7461-12-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23