BVT-14225
- Product Name
- BVT-14225
- CAS No.
- 376638-65-2
- Chemical Name
- BVT-14225
- Synonyms
- BVT-14225;BVT-14225, >98%;BVT14225;BVT 14225;BVT-14225, 10 mM in DMSO;inhibit,Inhibitor,BVT-14225,BVT14225;2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-n,n-diethylacetamide;4-Thiazoleacetamide,2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-;2-[2-(3-chloro-2-methylbenzenesulfonamido)-1,3-thiazol-4-yl]-N,N-diethylacetamide
- CBNumber
- CB72662984
- Molecular Formula
- C16H20ClN3O3S2
- Formula Weight
- 401.93
- MOL File
- 376638-65-2.mol
BVT-14225 Property
- Boiling point:
- 586.5±60.0 °C(Predicted)
- Density
- 1.373±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 27 mg/mL (67.18 mM)
- pka
- 6.34±0.10(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CM321672
- Product name
- 2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $884
- Updated
- 2021/12/16
- Product number
- CD11133137
- Product name
- 2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $937
- Updated
- 2021/12/16
- Product number
- DC8278
- Product name
- BVT-14225
- Purity
- >98%
- Packaging
- 1g
- Price
- $1900
- Updated
- 2021/12/16
BVT-14225 Chemical Properties,Usage,Production
Uses
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM.
References
[1] Barf T, et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2002 Aug 29;45(18):3813-5. DOI:10.1021/jm025530f
[2] Vicker N, et al. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9. DOI:10.1016/j.jsbmb.2007.03.023
BVT-14225 Preparation Products And Raw materials
Raw materials
Preparation Products
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