N-Boc-(S)-2-(MethylaMino)butyric acid
- Product Name
- N-Boc-(S)-2-(MethylaMino)butyric acid
- CAS No.
- 101759-74-4
- Chemical Name
- N-Boc-(S)-2-(MethylaMino)butyric acid
- Synonyms
- Boc-N-methyl-L-2-aminobutyric acid;N-Boc-(S)-2-(MethylaMino)butyric acid;(S)-2-[Boc-(methyl)amino]butanoic Acid;(S)-2-[(tert-Butoxycarbonyl)(methyl)amino]butyric,acid;(S)-2-((tert-Butoxycarbonyl)(methyl)amino)butanoic acid;Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, (S)-;Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, (2S)-
- CBNumber
- CB72664544
- Molecular Formula
- C10H19NO4
- Formula Weight
- 217.26
- MOL File
- 101759-74-4.mol
N-Boc-(S)-2-(MethylaMino)butyric acid Property
- Boiling point:
- 312.4±21.0 °C(Predicted)
- Density
- 1.089±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.01±0.10(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- -37.901° (C=1.00g/100ml, ETOH)
Safety
- HS Code
- 2924190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AS85691
- Product name
- N-Boc-(S)-2-(methylamino)butyric acid
- Purity
- 95+% ee
- Packaging
- 1g
- Price
- $178
- Updated
- 2021/12/16
- Product number
- OR452097
- Product name
- N-Boc-(S)-2-(methylamino)butyricacid
- Purity
- 97%
- Packaging
- 500mg
- Price
- $209
- Updated
- 2021/12/16
- Product number
- OR452097
- Product name
- N-Boc-(S)-2-(methylamino)butyricacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $314
- Updated
- 2021/12/16
- Product number
- AS85691
- Product name
- N-Boc-(S)-2-(methylamino)butyric acid
- Purity
- 95+% ee
- Packaging
- 5G
- Price
- $512
- Updated
- 2021/12/16
- Product number
- OR452097
- Product name
- N-Boc-(S)-2-(methylamino)butyricacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $940
- Updated
- 2021/12/16
N-Boc-(S)-2-(MethylaMino)butyric acid Chemical Properties,Usage,Production
Synthesis
34306-42-8
74-88-4
140224-14-2
Step 1: Iodomethane (2.45 mL, 39.4 mmol) was added to a solution of (S)-2-(tert-butoxycarbonylamino)butyric acid (1.00 g, 4.92 mmol) in tetrahydrofuran (THF, 16.4 mL) at 0 °C, followed by batchwise addition of sodium hydride (60% w/w dispersed in mineral oil, 590 mg, 14.8 mmol). The reaction mixture was gradually warmed to room temperature and stirred for 18 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched by careful addition of water. The reaction mixture was washed with ether (Et2O) and the aqueous layer was acidified with 1 M hydrochloric acid and then extracted with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate (NaHCO3), then dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give (S)-2-(tert-butoxycarbonyl(methyl)amino)butanoic acid (1.05 g, 98% yield) as a white solid. Mass spectrum (MS) m/z 240 (MNa+).
References
[1] Patent: US2015/225449, 2015, A1. Location in patent: Paragraph 0371
[2] Helvetica Chimica Acta, 1994, vol. 77, # 4, p. 1124 - 1165
[3] Tetrahedron, 1991, vol. 47, # 29, p. 5453 - 5462
N-Boc-(S)-2-(MethylaMino)butyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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