ChemicalBook > CAS DataBase List > N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-

Product Name
N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-
CAS No.
1263369-28-3
Chemical Name
N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-
Synonyms
CDK9-IN-2;CDK9 inhibitor 2;CDK9-IN-2, 10 mM in DMSO;inhibit,Inhibitor,Cyclin dependent kinase,CDK,CDK9IN2,CDK9 IN 2,CDK-9-IN-2;N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine;4-N-[5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamine;N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-;N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-[2,4'-bipyridine]-2',6-diamine;[2,4'-Bipyridine]-2',6-diamine, N2'-(trans-4-aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-
CBNumber
CB72666609
Molecular Formula
C23H25ClFN5
Formula Weight
425.93
MOL File
1263369-28-3.mol
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N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Property

Boiling point:
603.1±55.0 °C(Predicted)
Density 
1.302±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (117.39 mM; Need ultrasonic)
form 
Powder
pka
10.40±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-1252
Product name
CDK9-IN-2
Purity
99.84%
Packaging
10mg
Price
$360
Updated
2021/12/16
ApexBio Technology
Product number
A3295
Product name
CDK9inhibitor2
Packaging
5mg
Price
$419
Updated
2021/12/16
ApexBio Technology
Product number
A3295
Product name
CDK9inhibitor2
Packaging
10mg
Price
$541
Updated
2021/12/16
ChemScene
Product number
CS-1252
Product name
CDK9-IN-2
Purity
99.84%
Packaging
5mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-1252
Product name
CDK9-IN-2
Purity
99.84%
Packaging
50mg
Price
$960
Updated
2021/12/16
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N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Chemical Properties,Usage,Production

Description

CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.

Uses

CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.

in vitro

In Vitro:CDK9-IN-2 (200 nM) reduces the expression of MEPCE indicating that MEPCE is a pharmacodynamic (PD) marker for any CDK9 inhibitor. The expression of MCL1 protein is reduced 2 hours after treatment and is further reduced after 16 hour exposure to CDK9-IN-2 (500 nM)[1].

IC 50

CDK9: 5 nM (IC50, H929 multiple myeloma cell line)

References

References:[1]. Michel Faure, et al. Pharmacodynamic markers associated with cyclin-dependent kinase inhibitors. From PCT Int. Appl. (2012), WO 2012131594A1.

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Preparation Products And Raw materials

Raw materials

Preparation Products

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N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Suppliers

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1263369-28-3, N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-Related Search:


  • CDK9 inhibitor 2
  • N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-
  • CDK9-IN-2
  • N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-[2,4'-bipyridine]-2',6-diamine
  • [2,4'-Bipyridine]-2',6-diamine, N2'-(trans-4-aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-
  • inhibit,Inhibitor,Cyclin dependent kinase,CDK,CDK9IN2,CDK9 IN 2,CDK-9-IN-2
  • N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine
  • CDK9-IN-2, 10 mM in DMSO
  • 4-N-[5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamine
  • 1263369-28-3
  • C23H25ClFN5