ChemicalBook > CAS DataBase List > LY 2801653 dihydrochloride

LY 2801653 dihydrochloride

Product Name: LY 2801653 dihydrochloride
CAS No.: 1206801-37-7
Chemical Name: LY 2801653 dihydrochloride
Synonyms: CS-1046;LY2801653 HCl;LY2801653 2HCl;LY 2801653 dihydrochloride;LY-2801653 dihydrochloride;Merestinib dihydrochloride;LY2801653 (dihydrochloride);Merestinib(LY2801653 dihydrochloride);Merestinib dihydrochloride (LY2801653 dihydrochloride);LY-2801653 DIHYDROCHLORIDE; LY 2801653 DIHYDROCHLORIDE
CBNumber: CB72666654
Molecular Formula: C30H23ClF2N6O3
Formula Weight: 589
MOL File: 1206801-37-7.mol

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LY 2801653 dihydrochloride Property

storage temp.: Store at -20°C, sealed storage, away from moisture
solubility: DMSO: ≥ 100 mg/mL (159.88 mM)
form: Powder
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1438
Product name: Merestinibdihydrochloride
Purity: 99.02%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-1438
Product name: Merestinibdihydrochloride
Purity: 99.02%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-1438
Product name: Merestinibdihydrochloride
Purity: 99.02%
Packaging: 50mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-1438
Product name: Merestinibdihydrochloride
Purity: 99.02%
Packaging: 100mg
Price: $768
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180901
Product name: Merestinib(LY2801653 dihydrochloride)
Purity: >99%
Packaging: 100mg
Price: $1060.8
Updated: 2021/12/16

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LY 2801653 dihydrochloride Chemical Properties,Usage,Production

Uses

N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide dihydrochloride is used as a reactant/reagent in synthetic preparation of amidophenoxyindazoles as inhibitors of c-Met.

in vivo

Merestinib (LY2801653) demonstrates anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects. Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a pharmacodynamic residence time (K_off) of 0.00132 min^-1 and t_1/2 of 525 min. Merestinib (LY2801653) treatment inhibits MET phosphorylation with a composite TED50 (50 % target inhibition dose) of 1.2 mg/kg and a composite TED90 (90 % target inhibition dose) of 7.4 mg/kg^[1]. Merestinib (LY2801653) (20 mg/kg) reduces TFK-1 tumor growth significantly relative to vehicle control. Merestinib (LY2801653) inhibits the growth of intra- and extrahepatic CCC xenograft tumors^[2].

LY 2801653 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1206801-37-7, LY 2801653 dihydrochlorideRelated Search:

CS-1046

LY-2801653 DIHYDROCHLORIDE; LY 2801653 DIHYDROCHLORIDE;LY2801653

Merestinib(LY2801653 dihydrochloride)

LY 2801653 dihydrochloride

LY2801653 (dihydrochloride)

LY-2801653 dihydrochloride

N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide hydrochloride (1:2)

LY2801653 2HCl

LY-2801653 DIHYDROCHLORIDE; LY 2801653 DIHYDROCHLORIDE

Merestinib dihydrochloride (LY2801653 dihydrochloride)

LY2801653 HCl

Merestinib dihydrochloride

N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide dihydrochloride

1206801-37-7

C30H22F2N6O32HCl