Necrostatin-2 S enantioMer

Product Name: Necrostatin-2 S enantioMer
CAS No.: 852391-20-9
Chemical Name: Necrostatin-2 S enantioMer
Synonyms: Necrostatin-2 S enantioMer;Necrostatin 2 (S enantioMer);(5S)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5S)-
CBNumber: CB72666669
Molecular Formula: C13H12ClN3O2
Formula Weight: 277.71
MOL File: 852391-20-9.mol

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Necrostatin-2 S enantioMer Property

Density: 1.450±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (180.04 mM; Need ultrasonic)
form: Powder
pka: 8.48±0.70(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD31000600
Product name: Necrostatin2Senantiomer
Purity: 98+%
Packaging: 5mg
Price: $155
Updated: 2021/12/16

Chemenu

Product number: CM149084
Product name: (S)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
Purity: 95%+
Packaging: 10mg
Price: $259
Updated: 2021/12/16

Crysdot

Product number: CD31000600
Product name: Necrostatin2Senantiomer
Purity: 98+%
Packaging: 10mg
Price: $277
Updated: 2021/12/16

Chemenu

Product number: CM149084
Product name: (S)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
Purity: 95%+
Packaging: 50mg
Price: $648
Updated: 2021/12/16

Crysdot

Product number: CD31000600
Product name: Necrostatin2Senantiomer
Purity: 98+%
Packaging: 50mg
Price: $693
Updated: 2021/12/16

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Necrostatin-2 S enantioMer Chemical Properties,Usage,Production

Uses

Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2. Necrostatin 2 is a potent necroptosis inhibitor, acts as a RIPK1 inhibitor lacking the IDO-targeting effect. Target: RIPK1 [4] Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

References

[1] Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40. DOI:10.1016/j.bmcl.2007.10.024
[2] Takahashi N, et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 2012 Nov 29;3:e437. DOI:10.1038/cddis.2012.176
[3] Jagtap PG, Degterev A, Choi S, Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19;50(8):1886-95. DOI:10.1021/jm061016o
[4] Teng X, Degterev A, Jagtap P, Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5039-44. DOI:10.1016/j.bmcl.2005.07.077

Necrostatin-2 S enantioMer Preparation Products And Raw materials

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852391-20-9, Necrostatin-2 S enantioMerRelated Search:

Necrostatin 2 (S enantioMer)

Necrostatin-2 S enantioMer

(5S)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione

2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5S)-

852391-20-9