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tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate

Product Name
tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate
CAS No.
1298101-47-9
Chemical Name
tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate
Synonyms
(1s,3r)-3-amino-1-(boc-amino)cyclohexane;tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate;tert-butyl N-[(1S,3R)-3-aminocyclohexyl]carbamate;Carbamic acid,N-[(1S,3R)-3-aminocyclohexyl]-, 1,1-dimethylethyl ester
CBNumber
CB72666982
Molecular Formula
C11H22N2O2
Formula Weight
214.3
MOL File
1298101-47-9.mol
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tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate Property

Boiling point:
322.1±31.0 °C(Predicted)
Density 
1.02±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
12.40±0.40(Predicted)
Appearance
White to off-white Solid
optical activity
-32.6°(C=0.01g/mL, MEOH, 20°C, 589nm)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
9131DT
Product name
Tert-Butyl((1S,3R)-3-aminocyclohexyl)carbamate
Packaging
1g
Price
$532
Updated
2021/12/16
Ambeed
Product number
A189556
Product name
tert-Butyl((1S,3R)-3-aminocyclohexyl)carbamate
Purity
95%
Packaging
100mg
Price
$60
Updated
2021/12/16
Ambeed
Product number
A189556
Product name
tert-Butyl((1S,3R)-3-aminocyclohexyl)carbamate
Purity
95%
Packaging
250mg
Price
$95
Updated
2021/12/16
ACHEMBLOCK
Product number
L13449
Product name
(1S,3R)-3-Amino-1-(Boc-amino)cyclohexane
Purity
97%
Packaging
100MG
Price
$140
Updated
2021/12/16
Ambeed
Product number
A189556
Product name
tert-Butyl((1S,3R)-3-aminocyclohexyl)carbamate
Purity
95%
Packaging
1g
Price
$233
Updated
2021/12/16
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tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate Chemical Properties,Usage,Production

Synthesis

1261225-48-2

1298101-47-9

The general procedure for the synthesis of tert-butyl ((1S,3R)-3-aminocyclohexyl)carbamate from benzyl ((1R,3S)-cyclohexane-1,3-diyl)dicarbamate (dextro) was as follows: to tert-butyl ((1S,3R)-3-(benzyloxycarbonylamino)cyclohexylcarbamate (10 g, 28.4 mmol) in EtOH (473 mL) A 10% w/w Pd/C (450 mg) was added to the degassed solution. The reaction mixture was stirred under H2 (1 atm) atmosphere for 5 hours. Upon completion of the reaction, the mixture was filtered through a Celite pad (and washed with EtOH) and the filtrate was concentrated under reduced pressure to afford tert-butyl ((1S,3R)-3-aminocyclohexyl)carbamate (6.08 g, 28.4 mmol, 100% yield) as a white solid.

References

[1] Patent: WO2015/58140, 2015, A1. Location in patent: Paragraph 00310
[2] Patent: WO2015/154039, 2015, A2. Location in patent: Paragraph 248; 249; 446; 447
[3] Patent: WO2016/58544, 2016, A1. Location in patent: Paragraph 165; 166; 375

tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate manufacturers

Shanghai Yongzeng Technology Co.,Ltd
Product
(1S,3R)-3-Amino-1-(Boc-amino)cyclohexane 1298101-47-9
Price
US $0.00/gm
Min. Order
100gm
Purity
99%min
Supply Ability
100kgs
Release date
2024-09-03
Career Henan Chemical Co
Product
tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate 1298101-47-9
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

1298101-47-9, tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMateRelated Search:

(1R,3R)-(3-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester tert-butyl ((1R,3S)-3-hydroxycyclohexyl)carbamate cis-1-N-Boc-1,3-cyclohexyldiamine (1r,3s)-3-amino-1-(boc-amino)cyclohexane tert-Butyl ((1R,3R)-3-aminocyclohexyl)carbamate Carbamic acid, [(1R,3R)-3-aminocyclohexyl]-, 1,1-dimethylethyl ester, rel- (9CI) (1S,3R)-(3-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester Tert-Butyl((1S,3S)-3-hydroxycyclohexyl)carbaMate CarbaMic acid,N-[(1S,3S)-3-hydroxycyclohexyl]-1,1-diMethyethyester (1R,3S)-(3-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester tert-butyl ((1S,3S)-3-hydroxycyclohexyl)carbamate

  • tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate
  • (1s,3r)-3-amino-1-(boc-amino)cyclohexane
  • tert-butyl N-[(1S,3R)-3-aminocyclohexyl]carbamate
  • Carbamic acid,N-[(1S,3R)-3-aminocyclohexyl]-, 1,1-dimethylethyl ester
  • 1298101-47-9